This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2bov

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:50, 13 December 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='2bov' size='340' side='right'caption='[[2bov]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
<StructureSection load='2bov' size='340' side='right'caption='[[2bov]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2bov]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896] and [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1wca 1wca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOV FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2bov]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1wca 1wca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOV FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.66&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g24|1g24]], [[1gze|1gze]], [[1gzf|1gzf]], [[1uad|1uad]], [[1uzi|1uzi]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bov OCA], [https://pdbe.org/2bov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bov RCSB], [https://www.ebi.ac.uk/pdbsum/2bov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bov ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bov OCA], [https://pdbe.org/2bov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bov RCSB], [https://www.ebi.ac.uk/pdbsum/2bov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bov ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/RALA_HUMAN RALA_HUMAN]] Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.<ref>PMID:18756269</ref> <ref>PMID:19306925</ref> <ref>PMID:20005108</ref> [[https://www.uniprot.org/uniprot/ARC3_CBDP ARC3_CBDP]] ADP-ribosylates eukaryotic Rho and Rac proteins on an asparagine residue.
+
[https://www.uniprot.org/uniprot/ARC3_CBDP ARC3_CBDP] ADP-ribosylates eukaryotic Rho and Rac proteins on an asparagine residue.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 36: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bacillus botulinus van ermengem 1896]]
+
[[Category: Clostridium botulinum]]
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Acharya, K R]]
+
[[Category: Acharya KR]]
-
[[Category: Evans, H R]]
+
[[Category: Evans HR]]
-
[[Category: Holbourn, K P]]
+
[[Category: Holbourn KP]]
-
[[Category: Shone, C C]]
+
[[Category: Shone CC]]
-
[[Category: Sutton, J M]]
+
[[Category: Sutton JM]]
-
[[Category: Adp]]
+
-
[[Category: C3bot]]
+
-
[[Category: Exoenzyme]]
+
-
[[Category: Glycosyltransferase]]
+
-
[[Category: Gtp-binding]]
+
-
[[Category: Gtpase]]
+
-
[[Category: Lipoprotein]]
+
-
[[Category: Nad]]
+
-
[[Category: Prenylation]]
+
-
[[Category: Rala]]
+
-
[[Category: Ribosylating toxin]]
+
-
[[Category: Transferase]]
+

Current revision

Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase

PDB ID 2bov

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bov"
Personal tools