This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2byp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:58, 13 December 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
==CRYSTAL STRUCTURE OF APLYSIA CALIFORNICA ACHBP IN COMPLEX WITH ALPHA-CONOTOXIN IMI==
+
 
-
<StructureSection load='2byp' size='340' side='right' caption='[[2byp]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
+
==Crystal structure of Aplysia californica AChBP in complex with alpha- conotoxin ImI==
 +
<StructureSection load='2byp' size='340' side='right'caption='[[2byp]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2byp]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BYP FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2byp]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica] and [https://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BYP FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CY3:2-AMINO-3-MERCAPTO-PROPIONAMIDE'>CY3</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CY3:2-AMINO-3-MERCAPTO-PROPIONAMIDE'>CY3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cnl|1cnl]], [[1e74|1e74]], [[1e75|1e75]], [[1e76|1e76]], [[1g2g|1g2g]], [[1im1|1im1]], [[1imi|1imi]], [[2br7|2br7]], [[2br8|2br8]], [[2byn|2byn]], [[2byq|2byq]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2byp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2byp OCA], [https://pdbe.org/2byp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2byp RCSB], [https://www.ebi.ac.uk/pdbsum/2byp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2byp ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2byp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2byp OCA], [http://pdbe.org/2byp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2byp RCSB], [http://www.ebi.ac.uk/pdbsum/2byp PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/CA1_CONIM CA1_CONIM]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.<ref>PMID:8206995</ref>
+
[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/2byp_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/2byp_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 31: Line 31:
==See Also==
==See Also==
-
*[[Acetylcholine binding protein|Acetylcholine binding protein]]
+
*[[Acetylcholine binding protein 3D structures|Acetylcholine binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Aplca]]
+
[[Category: Aplysia californica]]
-
[[Category: Bourne, Y]]
+
[[Category: Conus imperialis]]
-
[[Category: Hansen, S B]]
+
[[Category: Large Structures]]
-
[[Category: Huxford, T]]
+
[[Category: Bourne Y]]
-
[[Category: Marchot, P]]
+
[[Category: Hansen SB]]
-
[[Category: Sulzenbacher, G]]
+
[[Category: Huxford T]]
-
[[Category: Taylor, P]]
+
[[Category: Marchot P]]
-
[[Category: Conotoxin]]
+
[[Category: Sulzenbacher G]]
-
[[Category: Nicotinic acetylcholine receptor complex]]
+
[[Category: Taylor P]]
-
[[Category: Receptor]]
+
-
[[Category: Receptor complex]]
+

Current revision

Crystal structure of Aplysia californica AChBP in complex with alpha- conotoxin ImI

PDB ID 2byp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2byp"
Personal tools