2c0z

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[[Image:2c0z.gif|left|200px]]
 
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{{Structure
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==The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides==
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|PDB= 2c0z |SIZE=350|CAPTION= <scene name='initialview01'>2c0z</scene>, resolution 1.60&Aring;
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<StructureSection load='2c0z' size='340' side='right'caption='[[2c0z]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Edo+Binding+Site+For+Chain+A'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[2c0z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_niveus_NCIMB_11891 Streptomyces niveus NCIMB 11891]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0Z FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0z OCA], [https://pdbe.org/2c0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0z RCSB], [https://www.ebi.ac.uk/pdbsum/2c0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0z ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0z OCA], [http://www.ebi.ac.uk/pdbsum/2c0z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c0z RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/NOVW_STRNV NOVW_STRNV] dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase that acts together with NovU to catalyze the formation of dTDP-4-keto-6-deoxy-5-C-methyl-L-lyxo-hexose from dTDP-4-keto-6-deoxy-D-glucose in the novobiocin biosynthesis pathway, an aminocoumarin family antibiotic that targets bacterial DNA gyrases.<ref>PMID:15752721</ref> <ref>PMID:16514445</ref>
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== Evolutionary Conservation ==
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'''THE 1.6 A RESOLUTION CRYSTAL STRUCTURE OF NOVW: A 4-KETO-6-DEOXY SUGAR EPIMERASE FROM THE NOVOBIOCIN BIOSYNTHETIC GENE CLUSTER OF STREPTOMYCES SPHEROIDES'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0z_consurf.spt"</scriptWhenChecked>
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2C0Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_caeruleus Streptomyces caeruleus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0Z OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Single protein]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Streptomyces caeruleus]]
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</jmolCheckbox>
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[[Category: Buttner, M J.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c0z ConSurf].
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[[Category: Field, R A.]]
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<div style="clear:both"></div>
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[[Category: Freel-Meyers, C L.]]
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== References ==
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[[Category: Jakimowicz, P.]]
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<references/>
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[[Category: Lawson, D M.]]
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__TOC__
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[[Category: Tello, M.]]
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</StructureSection>
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[[Category: Walsh, C T.]]
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[[Category: Large Structures]]
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[[Category: antibiotic biosynthesis]]
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[[Category: Streptomyces niveus NCIMB 11891]]
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[[Category: epimerase]]
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[[Category: Buttner MJ]]
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[[Category: isomerase]]
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[[Category: Field RA]]
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[[Category: rmlc-like cupin]]
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[[Category: Freel-Meyers CL]]
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[[Category: Jakimowicz P]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:14:45 2008''
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[[Category: Lawson DM]]
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[[Category: Tello M]]
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[[Category: Walsh CT]]

Current revision

The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides

PDB ID 2c0z

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