This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2c0z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:01, 13 December 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2c0z.gif|left|200px]]
 
-
<!--
+
==The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides==
-
The line below this paragraph, containing "STRUCTURE_2c0z", creates the "Structure Box" on the page.
+
<StructureSection load='2c0z' size='340' side='right'caption='[[2c0z]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2c0z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_niveus_NCIMB_11891 Streptomyces niveus NCIMB 11891]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0Z FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_2c0z| PDB=2c0z | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0z OCA], [https://pdbe.org/2c0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0z RCSB], [https://www.ebi.ac.uk/pdbsum/2c0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0z ProSAT]</span></td></tr>
-
 
+
</table>
-
'''THE 1.6 A RESOLUTION CRYSTAL STRUCTURE OF NOVW: A 4-KETO-6-DEOXY SUGAR EPIMERASE FROM THE NOVOBIOCIN BIOSYNTHETIC GENE CLUSTER OF STREPTOMYCES SPHEROIDES'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/NOVW_STRNV NOVW_STRNV] dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase that acts together with NovU to catalyze the formation of dTDP-4-keto-6-deoxy-5-C-methyl-L-lyxo-hexose from dTDP-4-keto-6-deoxy-D-glucose in the novobiocin biosynthesis pathway, an aminocoumarin family antibiotic that targets bacterial DNA gyrases.<ref>PMID:15752721</ref> <ref>PMID:16514445</ref>
-
 
+
== Evolutionary Conservation ==
-
==About this Structure==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
2C0Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_caeruleus Streptomyces caeruleus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0Z OCA].
+
Check<jmol>
-
[[Category: Single protein]]
+
<jmolCheckbox>
-
[[Category: Streptomyces caeruleus]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0z_consurf.spt"</scriptWhenChecked>
-
[[Category: Buttner, M J.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: Field, R A.]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: Freel-Meyers, C L.]]
+
</jmolCheckbox>
-
[[Category: Jakimowicz, P.]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c0z ConSurf].
-
[[Category: Lawson, D M.]]
+
<div style="clear:both"></div>
-
[[Category: Tello, M.]]
+
== References ==
-
[[Category: Walsh, C T.]]
+
<references/>
-
[[Category: Antibiotic biosynthesis]]
+
__TOC__
-
[[Category: Epimerase]]
+
</StructureSection>
-
[[Category: Isomerase]]
+
[[Category: Large Structures]]
-
[[Category: Rmlc-like cupin]]
+
[[Category: Streptomyces niveus NCIMB 11891]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:04:44 2008''
+
[[Category: Buttner MJ]]
 +
[[Category: Field RA]]
 +
[[Category: Freel-Meyers CL]]
 +
[[Category: Jakimowicz P]]
 +
[[Category: Lawson DM]]
 +
[[Category: Tello M]]
 +
[[Category: Walsh CT]]

Current revision

The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides

PDB ID 2c0z

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c0z"
Personal tools