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2c1i

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==STRUCTURE OF STREPTOCOCCUS PNEMONIAE PEPTIDOGLYCAN DEACETYLASE (SPPGDA) D 275 N MUTANT.==
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<StructureSection load='2c1i' size='340' side='right' caption='[[2c1i]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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==Structure of Streptococcus pneumoniae peptidoglycan deacetylase (SpPgdA) D 275 N Mutant.==
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<StructureSection load='2c1i' size='340' side='right'caption='[[2c1i]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2c1i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C1I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2c1i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C1I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c1g|2c1g]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylglucosamine_deacetylase N-acetylglucosamine deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.33 3.5.1.33] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1i OCA], [https://pdbe.org/2c1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c1i RCSB], [https://www.ebi.ac.uk/pdbsum/2c1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c1i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1i OCA], [http://pdbe.org/2c1i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c1i RCSB], [http://www.ebi.ac.uk/pdbsum/2c1i PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PGDA_STRR6 PGDA_STRR6] Catalyzes the deacetylation of N-acetylglucosamine (GlcNAc) residues in peptidoglycan, a modification that confers host lysozyme resistance and contributes to pneumococcal virulence.<ref>PMID:10781617</ref> <ref>PMID:12438406</ref> <ref>PMID:16221761</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/2c1i_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/2c1i_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: N-acetylglucosamine deacetylase]]
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[[Category: Large Structures]]
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[[Category: Strr6]]
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[[Category: Streptococcus pneumoniae R6]]
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[[Category: Aalten, D M.F Van]]
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[[Category: Blair DE]]
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[[Category: Blair, D E]]
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[[Category: MacRae JI]]
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[[Category: Macrae, J I]]
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[[Category: Schuttelkopf AW]]
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[[Category: Schuttelkopf, A W]]
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[[Category: Van Aalten DMF]]
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[[Category: Carbohydrate esterase]]
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[[Category: Ce-4]]
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[[Category: D275n mutant]]
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[[Category: Hydrolase]]
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[[Category: Metalloenzyme]]
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[[Category: Peptidoglycan deacetylase]]
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Current revision

Structure of Streptococcus pneumoniae peptidoglycan deacetylase (SpPgdA) D 275 N Mutant.

PDB ID 2c1i

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