2c46

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[[Image:2c46.gif|left|200px]]<br /><applet load="2c46" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2c46, resolution 1.60&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE HUMAN RNA GUANYLYLTRANSFERASE AND 5'-PHOSPHATASE'''<br />
 
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==About this Structure==
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==CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase==
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2C46 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/mRNA_guanylyltransferase mRNA guanylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.50 2.7.7.50] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C46 OCA].
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<StructureSection load='2c46' size='340' side='right'caption='[[2c46]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2c46]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C46 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c46 OCA], [https://pdbe.org/2c46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c46 RCSB], [https://www.ebi.ac.uk/pdbsum/2c46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c46 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCE1_HUMAN MCE1_HUMAN] Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c46_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c46 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: mRNA guanylyltransferase]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Bunkoczi G]]
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[[Category: Bunkoczi, G.]]
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[[Category: Debreczeni J]]
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[[Category: Debreczeni, J.]]
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[[Category: Edwards A]]
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[[Category: Delft, E Von.]]
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[[Category: Gileadi O]]
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[[Category: Edwards, A.]]
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[[Category: Johansson C]]
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[[Category: Gileadi, O.]]
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[[Category: Knapp S]]
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[[Category: Johansson, C.]]
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[[Category: Longman E]]
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[[Category: Knapp, S.]]
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[[Category: SavitskySmee P]]
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[[Category: Longman, E.]]
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[[Category: Smee C]]
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[[Category: Savitskysmee, P.]]
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[[Category: Sundstrom M]]
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[[Category: Smee, C.]]
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[[Category: Ugochukwu E]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Ugochukwu, E.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: alternative splicing]]
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[[Category: guanylyltransferase]]
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[[Category: hydrolase]]
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[[Category: mrna capping]]
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[[Category: mrna processing]]
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[[Category: multifunctional enzyme]]
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[[Category: nuclear protein]]
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[[Category: nucleotidyltransferase]]
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[[Category: phosphatase]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:44:47 2008''
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Current revision

CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase

PDB ID 2c46

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