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2c47

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==Structure of casein kinase 1 gamma 2==
==Structure of casein kinase 1 gamma 2==
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<StructureSection load='2c47' size='340' side='right' caption='[[2c47]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='2c47' size='340' side='right'caption='[[2c47]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2c47]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C47 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2c47]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C47 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5ID:(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL'>5ID</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ID:(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL'>5ID</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c47 OCA], [http://pdbe.org/2c47 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c47 RCSB], [http://www.ebi.ac.uk/pdbsum/2c47 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c47 OCA], [https://pdbe.org/2c47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c47 RCSB], [https://www.ebi.ac.uk/pdbsum/2c47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c47 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KC1G2_HUMAN KC1G2_HUMAN]] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.<ref>PMID:15342122</ref> <ref>PMID:15077195</ref> <ref>PMID:18794808</ref> <ref>PMID:19005213</ref>
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[https://www.uniprot.org/uniprot/KC1G2_HUMAN KC1G2_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.<ref>PMID:15342122</ref> <ref>PMID:15077195</ref> <ref>PMID:18794808</ref> <ref>PMID:19005213</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c47_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c47_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Casein kinase|Casein kinase]]
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*[[Casein kinase 3D structures|Casein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Amos, A]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Amos A]]
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[[Category: Ball, L]]
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[[Category: Arrowsmith C]]
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[[Category: Bullock, A]]
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[[Category: Ball L]]
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[[Category: Bunkoczi, G]]
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[[Category: Bullock A]]
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[[Category: Das, S]]
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[[Category: Bunkoczi G]]
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[[Category: Debreczeni, J]]
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[[Category: Das S]]
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[[Category: Delft, F Von]]
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[[Category: Debreczeni J]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Eswaran, J]]
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[[Category: Eswaran J]]
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[[Category: Fedorov, O]]
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[[Category: Fedorov O]]
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[[Category: Knapp, S]]
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[[Category: Knapp S]]
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[[Category: Rellos, P]]
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[[Category: Rellos P]]
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[[Category: Sobott, F]]
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[[Category: Sobott F]]
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[[Category: Sundstrom, M]]
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[[Category: Sundstrom M]]
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[[Category: Turnbull, A]]
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[[Category: Turnbull A]]
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[[Category: Ugochukwu, E]]
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[[Category: Ugochukwu E]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Actin cytoskeleton organisation]]
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[[Category: Von Delft F]]
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[[Category: Atp-binding]]
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[[Category: Serine/threonine kinase]]
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[[Category: Transferase]]
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[[Category: Wnt signaling pathway]]
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Current revision

Structure of casein kinase 1 gamma 2

PDB ID 2c47

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