This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2c4k
From Proteopedia
(Difference between revisions)
| (19 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2c4k.gif|left|200px]]<br /> | ||
| - | <applet load="2c4k" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2c4k, resolution 2.65Å" /> | ||
| - | '''CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE-ASSOCIATED PROTEIN 39 (PAP39)'''<br /> | ||
| - | == | + | ==Crystal structure of human phosphoribosylpyrophosphate synthetase- associated protein 39 (PAP39)== |
| - | + | <StructureSection load='2c4k' size='340' side='right'caption='[[2c4k]], [[Resolution|resolution]] 2.65Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2c4k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C4K FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c4k OCA], [https://pdbe.org/2c4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c4k RCSB], [https://www.ebi.ac.uk/pdbsum/2c4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c4k ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KPRA_HUMAN KPRA_HUMAN] Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c4k_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c4k ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | + | [[Category: Berglund H]] | |
| - | [[Category: Berglund | + | [[Category: Edwards A]] |
| - | [[Category: Edwards | + | [[Category: Ehn M]] |
| - | [[Category: Ehn | + | [[Category: Flodin S]] |
| - | [[Category: Flodin | + | [[Category: Graslund S]] |
| - | [[Category: Graslund | + | [[Category: Hallberg BM]] |
| - | [[Category: Hallberg | + | [[Category: Hammarstrom M]] |
| - | [[Category: Hammarstrom | + | [[Category: Holmberg Schiavone L]] |
| - | [[Category: Kotenyova | + | [[Category: Kotenyova T]] |
| - | [[Category: Kursula | + | [[Category: Kursula P]] |
| - | [[Category: Nilsson-Ehle | + | [[Category: Nilsson-Ehle P]] |
| - | [[Category: Nordlund | + | [[Category: Nordlund P]] |
| - | [[Category: Ogg | + | [[Category: Ogg D]] |
| - | [[Category: Persson | + | [[Category: Persson C]] |
| - | [[Category: Sagemark | + | [[Category: Sagemark J]] |
| - | + | [[Category: Schuler H]] | |
| - | [[Category: Schuler | + | [[Category: Stenmark P]] |
| - | [[Category: Stenmark | + | [[Category: Sundstrom M]] |
| - | [[Category: Sundstrom | + | [[Category: Thorsell AG]] |
| - | [[Category: Thorsell | + | [[Category: Van Den Berg S]] |
| - | [[Category: | + | [[Category: Weigelt J]] |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of human phosphoribosylpyrophosphate synthetase- associated protein 39 (PAP39)
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith C | Berglund H | Edwards A | Ehn M | Flodin S | Graslund S | Hallberg BM | Hammarstrom M | Holmberg Schiavone L | Kotenyova T | Kursula P | Nilsson-Ehle P | Nordlund P | Ogg D | Persson C | Sagemark J | Schuler H | Stenmark P | Sundstrom M | Thorsell AG | Van Den Berg S | Weigelt J
