This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2cen

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:15, 13 December 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==P1' Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold==
==P1' Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold==
-
<StructureSection load='2cen' size='340' side='right' caption='[[2cen]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+
<StructureSection load='2cen' size='340' side='right'caption='[[2cen]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2cen]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CEN FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2cen]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CEN FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4AH:{(1S)-1-[N-[(2S)-2-HYDROXY-2-((1S,2R)-2-HYDROXY-INDAN-1-YLCARBAMOYL)-3-PHENYL-PROPYL]-N-[4-(PYRIDINE-2-YL)-BENZYL]-HYDRAZINOCARBONYL]-2,2-DIMETHYL-PROPYL}-CARBAMIC+ACID+METHYL+ESTER'>4AH</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wbk|1wbk]], [[1wbm|1wbm]], [[2cej|2cej]], [[2cem|2cem]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4AH:{(1S)-1-[N-[(2S)-2-HYDROXY-2-((1S,2R)-2-HYDROXY-INDAN-1-YLCARBAMOYL)-3-PHENYL-PROPYL]-N-[4-(PYRIDINE-2-YL)-BENZYL]-HYDRAZINOCARBONYL]-2,2-DIMETHYL-PROPYL}-CARBAMIC+ACID+METHYL+ESTER'>4AH</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cen OCA], [https://pdbe.org/2cen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cen RCSB], [https://www.ebi.ac.uk/pdbsum/2cen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cen ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cen OCA], [http://pdbe.org/2cen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cen RCSB], [http://www.ebi.ac.uk/pdbsum/2cen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cen ProSAT]</span></td></tr>
+
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q5RZ09_9HIV1 Q5RZ09_9HIV1]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 32: Line 33:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: HIV-1 retropepsin]]
+
[[Category: Human immunodeficiency virus 1]]
-
[[Category: Ekegren, J K]]
+
[[Category: Large Structures]]
-
[[Category: Ginman, N]]
+
[[Category: Ekegren JK]]
-
[[Category: Hallberg, A]]
+
[[Category: Ginman N]]
-
[[Category: Johansson, A]]
+
[[Category: Hallberg A]]
-
[[Category: Larhed, M]]
+
[[Category: Johansson A]]
-
[[Category: Samuelsson, B]]
+
[[Category: Larhed M]]
-
[[Category: Unge, T]]
+
[[Category: Samuelsson B]]
-
[[Category: Wallberg, H]]
+
[[Category: Unge T]]
-
[[Category: Aspartyl protease]]
+
[[Category: Wallberg H]]
-
[[Category: Hiv-1]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Protease]]
+

Current revision

P1' Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold

PDB ID 2cen

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2cen"
Personal tools