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2cfi

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==THE HYDROLASE DOMAIN OF HUMAN 10-FTHFD IN COMPLEX WITH 6-FORMYLTETRAHYDROPTERIN==
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<StructureSection load='2cfi' size='340' side='right' caption='[[2cfi]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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==The hydrolase domain of human 10-FTHFD in complex with 6- formyltetrahydropterin==
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<StructureSection load='2cfi' size='340' side='right'caption='[[2cfi]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2cfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2cfi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZZZ:6-FORMYLTETRAHYDROPTERIN'>ZZZ</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bw0|2bw0]], [[2cq8|2cq8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZZZ:6-FORMYLTETRAHYDROPTERIN'>ZZZ</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyltetrahydrofolate_dehydrogenase Formyltetrahydrofolate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.6 1.5.1.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfi OCA], [https://pdbe.org/2cfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfi RCSB], [https://www.ebi.ac.uk/pdbsum/2cfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfi ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfi RCSB], [http://www.ebi.ac.uk/pdbsum/2cfi PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/AL1L1_HUMAN AL1L1_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfi_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfi_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cfi ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2cfi" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Aldehyde dehydrogenase|Aldehyde dehydrogenase]]
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Formyltetrahydrofolate dehydrogenase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Edwards, A.]]
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[[Category: Arrowsmith C]]
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[[Category: Ehn, M.]]
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[[Category: Edwards A]]
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[[Category: Graslund, S.]]
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[[Category: Ehn M]]
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[[Category: Hallberg, M.]]
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[[Category: Graslund S]]
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[[Category: Hammarstrom, M.]]
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[[Category: Hallberg M]]
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[[Category: Kotenyova, T.]]
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[[Category: Hammarstrom M]]
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[[Category: Kursula, P.]]
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[[Category: Kotenyova T]]
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[[Category: Nilsson-Ehle, P.]]
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[[Category: Kursula P]]
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[[Category: Nordlund, P.]]
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[[Category: Nilsson-Ehle P]]
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[[Category: Ogg, D J.]]
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[[Category: Nordlund P]]
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[[Category: Persson, C.]]
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[[Category: Ogg DJ]]
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[[Category: Sagemark, J.]]
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[[Category: Persson C]]
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[[Category: Schuler, H.]]
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[[Category: Sagemark J]]
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[[Category: Stenmark, P.]]
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[[Category: Schuler H]]
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[[Category: Sundstrom, M.]]
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[[Category: Stenmark P]]
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[[Category: Thorsell, A.]]
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[[Category: Sundstrom M]]
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[[Category: Weigelt, J.]]
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[[Category: Thorsell A]]
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[[Category: Folate binding]]
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[[Category: Weigelt J]]
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[[Category: Nadp]]
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[[Category: One-carbon metabolism]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphopantetheine]]
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[[Category: Tetrahydrofolate]]
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Current revision

The hydrolase domain of human 10-FTHFD in complex with 6- formyltetrahydropterin

PDB ID 2cfi

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