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2cjf

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(New page: 200px<br /> <applet load="2cjf" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cjf, resolution 1.95&Aring;" /> '''TYPE II DEHYDROQUIN...)
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[[Image:2cjf.gif|left|200px]]<br />
 
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<applet load="2cjf" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2cjf, resolution 1.95&Aring;" />
 
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'''TYPE II DEHYDROQUINASE INHIBITOR COMPLEX'''<br />
 
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==About this Structure==
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==TYPE II DEHYDROQUINASE INHIBITOR COMPLEX==
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2CJF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]] with PO4, RP4, TRS and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CJF OCA]].
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<StructureSection load='2cjf' size='340' side='right'caption='[[2cjf]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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[[Category: Single protein]]
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== Structural highlights ==
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[[Category: Streptomyces coelicolor]]
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<table><tr><td colspan='2'>[[2cjf]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CJF FirstGlance]. <br>
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[[Category: Abell, A.D.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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[[Category: Abell, C.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RP4:(1S,4S,5S)-1,4,5-TRIHYDROXY-3-[3-(PHENYLTHIO)PHENYL]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>RP4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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[[Category: Lapthorn, A.J.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjf OCA], [https://pdbe.org/2cjf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cjf RCSB], [https://www.ebi.ac.uk/pdbsum/2cjf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjf ProSAT]</span></td></tr>
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[[Category: Payne, R.J.]]
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</table>
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[[Category: Riboldi-Tunnicliffe, A.]]
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== Function ==
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[[Category: GOL]]
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[https://www.uniprot.org/uniprot/AROQ_STRCO AROQ_STRCO] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
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[[Category: PO4]]
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== Evolutionary Conservation ==
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[[Category: RP4]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: TRS]]
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Check<jmol>
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[[Category: amino-acid biosynthesis]]
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<jmolCheckbox>
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[[Category: aromatic amino acid biosynthesis]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/2cjf_consurf.spt"</scriptWhenChecked>
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[[Category: dehydroquinase]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: dehydroquinate]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: drug design]]
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</jmolCheckbox>
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[[Category: lyase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cjf ConSurf].
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[[Category: shikimate pathway]]
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 21:00:11 2007''
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==See Also==
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*[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Streptomyces coelicolor]]
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[[Category: Abell AD]]
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[[Category: Abell C]]
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[[Category: Lapthorn AJ]]
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[[Category: Payne RJ]]
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[[Category: Riboldi-Tunnicliffe A]]

Current revision

TYPE II DEHYDROQUINASE INHIBITOR COMPLEX

PDB ID 2cjf

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