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2clz

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==MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND PBM1 PEPTIDE==
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<StructureSection load='2clz' size='340' side='right' caption='[[2clz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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==Mhc Class I Natural Mutant H-2Kbm8 Heavy Chain Complexed With beta-2 Microglobulin and pBM1 peptide==
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<StructureSection load='2clz' size='340' side='right'caption='[[2clz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2clz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CLZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2clz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CLZ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a1m|1a1m]], [[1a1n|1a1n]], [[1a1o|1a1o]], [[1akj|1akj]], [[1b3j|1b3j]], [[1bd2|1bd2]], [[1bii|1bii]], [[1ce6|1ce6]], [[1ddh|1ddh]], [[1fo0|1fo0]], [[1fyt|1fyt]], [[1fzj|1fzj]], [[1fzk|1fzk]], [[1fzm|1fzm]], [[1fzo|1fzo]], [[1g7p|1g7p]], [[1g7q|1g7q]], [[1ha5|1ha5]], [[1hqr|1hqr]], [[1hxy|1hxy]], [[1icf|1icf]], [[1iie|1iie]], [[1im3|1im3]], [[1j8h|1j8h]], [[1je6|1je6]], [[1jwm|1jwm]], [[1jws|1jws]], [[1jwu|1jwu]], [[1k2d|1k2d]], [[1k8d|1k8d]], [[1kbg|1kbg]], [[1kg0|1kg0]], [[1kj2|1kj2]], [[1kj3|1kj3]], [[1kjm|1kjm]], [[1kjv|1kjv]], [[1kpu|1kpu]], [[1kpv|1kpv]], [[1ldp|1ldp]], [[1lo5|1lo5]], [[1mhc|1mhc]], [[1nam|1nam]], [[1osz|1osz]], [[1p1z|1p1z]], [[1qlf|1qlf]], [[1qo3|1qo3]], [[1rjy|1rjy]], [[1rjz|1rjz]], [[1rk0|1rk0]], [[1rk1|1rk1]], [[1seb|1seb]], [[1vac|1vac]], [[1vad|1vad]], [[1wbx|1wbx]], [[1wby|1wby]], [[1wbz|1wbz]], [[1yn6|1yn6]], [[1yn7|1yn7]], [[1zs8|1zs8]], [[2cii|2cii]], [[2clv|2clv]], [[2f74|2f74]], [[2fwo|2fwo]], [[2vaa|2vaa]], [[2vab|2vab]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2clz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2clz OCA], [http://pdbe.org/2clz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2clz RCSB], [http://www.ebi.ac.uk/pdbsum/2clz PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2clz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2clz OCA], [https://pdbe.org/2clz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2clz RCSB], [https://www.ebi.ac.uk/pdbsum/2clz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2clz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/RBM5_MOUSE RBM5_MOUSE]] Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity). [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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[https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE] Involved in the presentation of foreign antigens to the immune system.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/2clz_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/2clz_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[Major histocompatibility complex|Major histocompatibility complex]]
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*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC I 3D structures|MHC I 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Auphan-Anezin, N]]
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[[Category: Mus musculus]]
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[[Category: Barrett-Wilt, G A]]
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[[Category: Auphan-Anezin N]]
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[[Category: Guimezanes, A]]
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[[Category: Barrett-Wilt GA]]
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[[Category: Hunt, D F]]
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[[Category: Guimezanes A]]
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[[Category: Malissen, B]]
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[[Category: Hunt DF]]
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[[Category: Mazza, C]]
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[[Category: Malissen B]]
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[[Category: Montero-Julian, F]]
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[[Category: Mazza C]]
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[[Category: Roussel, A]]
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[[Category: Montero-Julian F]]
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[[Category: Schmitt-Verhulst, A M]]
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[[Category: Roussel A]]
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[[Category: Alloreactivity]]
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[[Category: Schmitt-Verhulst AM]]
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[[Category: Class i mhc]]
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[[Category: Glycoprotein]]
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[[Category: H-2kbm8]]
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[[Category: Immune response]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin domain]]
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[[Category: Membrane]]
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[[Category: Mhc i]]
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[[Category: Transmembrane]]
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Current revision

Mhc Class I Natural Mutant H-2Kbm8 Heavy Chain Complexed With beta-2 Microglobulin and pBM1 peptide

PDB ID 2clz

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