This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.


Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2cnv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:24, 13 December 2023) (edit) (undo)
 
(17 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2cnv.gif|left|200px]]<br />
 
-
<applet load="2cnv" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2cnv, resolution 2.00&Aring;" />
 
-
'''SAICAR-SYNTHASE FROM SACCHAROMYCES CEREVISIAE COMPLEXED SAICAR'''<br />
 
-
==About this Structure==
+
==SAICAR-synthase from Saccharomyces cerevisiae complexed SAICAR==
-
2CNV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with SO4, ACE, ASP and SSS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazolesuccinocarboxamide_synthase Phosphoribosylaminoimidazolesuccinocarboxamide synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.6 6.3.2.6]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CNV OCA]].
+
<StructureSection load='2cnv' size='340' side='right'caption='[[2cnv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
[[Category: Phosphoribosylaminoimidazolesuccinocarboxamide synthase]]
+
== Structural highlights ==
-
[[Category: Saccharomyces cerevisiae]]
+
<table><tr><td colspan='2'>[[2cnv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CNV FirstGlance]. <br>
-
[[Category: Single protein]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
[[Category: Antonyuk, S.V.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SSS:N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC+ACID'>SSS</scene></td></tr>
-
[[Category: Barynin, V.V.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cnv OCA], [https://pdbe.org/2cnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cnv RCSB], [https://www.ebi.ac.uk/pdbsum/2cnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cnv ProSAT]</span></td></tr>
-
[[Category: Grebenko, A.I.]]
+
</table>
-
[[Category: Lamzin, V.S.]]
+
== Function ==
-
[[Category: Levdikov, V.M.]]
+
[https://www.uniprot.org/uniprot/PUR7_YEAST PUR7_YEAST]
-
[[Category: Melik-Adamyan, W.R.]]
+
== Evolutionary Conservation ==
-
[[Category: Popov, A.N.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: Urusova, D.V.]]
+
Check<jmol>
-
[[Category: ACE]]
+
<jmolCheckbox>
-
[[Category: ASP]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cn/2cnv_consurf.spt"</scriptWhenChecked>
-
[[Category: SO4]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: SSS]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: acetylation]]
+
</jmolCheckbox>
-
[[Category: atpbinding protein]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cnv ConSurf].
-
[[Category: phosphoribosylaminoimidazolesuccinocarboxamide (saicar) syn ligase]]
+
<div style="clear:both"></div>
-
[[Category: purine biosynthesis]]
+
-
[[Category: synthetase]]
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:13:54 2007''
+
==See Also==
 +
*[[SAICAR synthetase|SAICAR synthetase]]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Saccharomyces cerevisiae]]
 +
[[Category: Antonyuk SV]]
 +
[[Category: Barynin VV]]
 +
[[Category: Grebenko AI]]
 +
[[Category: Lamzin VS]]
 +
[[Category: Levdikov VM]]
 +
[[Category: Melik-Adamyan VR]]
 +
[[Category: Popov AN]]
 +
[[Category: Urusova DV]]

Current revision

SAICAR-synthase from Saccharomyces cerevisiae complexed SAICAR

PDB ID 2cnv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools