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2izr

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Structure of casein kinase gamma 3 in complex with inhibitor

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Retrieved from "http://52.214.119.220/wiki/index.php/2izr"

@@ Line 3: / Line 3: @@
 <StructureSection load='2izr' size='340' side='right'caption='[[2izr]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2izr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IZR FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2izr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZR FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRK:{(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE'>BRK</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2chl|2chl]], [[2izs|2izs]], [[2izt|2izt]], [[2izu|2izu]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRK:{(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE'>BRK</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2izr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izr OCA], [https://pdbe.org/2izr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2izr RCSB], [https://www.ebi.ac.uk/pdbsum/2izr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2izr ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2izr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izr OCA], [http://pdbe.org/2izr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2izr RCSB], [http://www.ebi.ac.uk/pdbsum/2izr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2izr ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/KC1G3_HUMAN KC1G3_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 24: / Line 25: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Arrowsmith C]]
-[[Category: Arrowsmith, C]]
+[[Category: Bunkoczi G]]
-[[Category: Bunkoczi, G]]
+[[Category: Das S]]
-[[Category: Das, S]]
+[[Category: Debreczeni JE]]
-[[Category: Debreczeni, J E]]
+[[Category: Edwards A]]
-[[Category: Delft, F von]]
+[[Category: Fedorov O]]
-[[Category: Edwards, A]]
+[[Category: Gileadi O]]
-[[Category: Fedorov, O]]
+[[Category: Knapp S]]
-[[Category: Gileadi, O]]
+[[Category: Rellos P]]
-[[Category: Knapp, S]]
+[[Category: Salah E]]
-[[Category: Rellos, P]]
+[[Category: Savitsky P]]
-[[Category: Salah, E]]
+[[Category: Sundstrom M]]
-[[Category: Savitsky, P]]
+[[Category: Weigelt J]]
-[[Category: Sundstrom, M]]
+[[Category: Von Delft F]]
-[[Category: Weigelt, J]]
-[[Category: Alternative splicing]]
-[[Category: Atp-binding]]
-[[Category: Kinase]]
-[[Category: Nucleotide-binding]]
-[[Category: Phosphorylation]]
-[[Category: Serine/threonine kinase]]
-[[Category: Serine/threonine-protein kinase]]
-[[Category: Transferase]]
-[[Category: Wnt signaling pathway]]

2izr

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Current revision

Structure of casein kinase gamma 3 in complex with inhibitor

Structural highlights

Function

Evolutionary Conservation

See Also

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