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2j12

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==AD37 FIBRE HEAD IN COMPLEX WITH CAR D1==
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<StructureSection load='2j12' size='340' side='right' caption='[[2j12]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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==Ad37 fibre head in complex with CAR D1==
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<StructureSection load='2j12' size='340' side='right'caption='[[2j12]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2j12]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Adenovirus_type_37 Adenovirus type 37] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J12 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2j12]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_adenovirus_D37 Human adenovirus D37]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J12 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1uxa|1uxa]], [[1uxb|1uxb]], [[1uxe|1uxe]], [[1eaj|1eaj]], [[1f5w|1f5w]], [[1jew|1jew]], [[1kac|1kac]], [[1p69|1p69]], [[1p6a|1p6a]], [[1rsf|1rsf]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j12 OCA], [http://pdbe.org/2j12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j12 RCSB], [http://www.ebi.ac.uk/pdbsum/2j12 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j12 OCA], [https://pdbe.org/2j12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j12 RCSB], [https://www.ebi.ac.uk/pdbsum/2j12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j12 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CXAR_HUMAN CXAR_HUMAN]] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.<ref>PMID:9096397</ref> <ref>PMID:11734628</ref> <ref>PMID:12297051</ref> <ref>PMID:15800062</ref>
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[https://www.uniprot.org/uniprot/Q80S15_9ADEN Q80S15_9ADEN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/2j12_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/2j12_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j12 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adenovirus type 37]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Human adenovirus D37]]
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[[Category: Billet, O]]
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[[Category: Large Structures]]
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[[Category: Cusac, S]]
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[[Category: Billet O]]
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[[Category: Kremer, E J]]
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[[Category: Cusack S]]
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[[Category: Lortat-Jacob, H]]
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[[Category: Kremer EJ]]
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[[Category: Seiradake, E]]
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[[Category: Lortat-Jacob H]]
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[[Category: Ad37]]
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[[Category: Seiradake E]]
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[[Category: Adenovirus]]
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[[Category: Car]]
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[[Category: Cell adhesion]]
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[[Category: Complex]]
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[[Category: Coxsackievirus]]
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[[Category: Glycoprotein]]
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[[Category: Had37]]
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[[Category: Host-virus interaction]]
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[[Category: Immunoglobulin domain]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Palmitate]]
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[[Category: Phosphorylation]]
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[[Category: Receptor]]
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[[Category: Tight junction]]
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[[Category: Transmembrane]]
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[[Category: Viral protein-receptor complex]]
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[[Category: Viral protein/receptor]]
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Current revision

Ad37 fibre head in complex with CAR D1

PDB ID 2j12

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