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2j14

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==3,4,5-TRISUBSTITUTED ISOXAZOLES AS NOVEL PPARDELTA AGONISTS: PART2==
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<StructureSection load='2j14' size='340' side='right' caption='[[2j14]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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==3,4,5-Trisubstituted Isoxazoles as Novel PPARdelta Agonists: Part2==
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<StructureSection load='2j14' size='340' side='right'caption='[[2j14]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2j14]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J14 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2j14]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J14 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNI:(3-{4-[2-(2,4-DICHLORO-PHENOXY)-ETHYLCARBAMOYL]-5-PHENYL-ISOXAZOL-3-YL}-PHENYL)-ACETIC+ACID'>GNI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gwx|1gwx]], [[1y0s|1y0s]], [[2awh|2awh]], [[2b50|2b50]], [[2baw|2baw]], [[2gwx|2gwx]], [[3gwx|3gwx]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNI:(3-{4-[2-(2,4-DICHLORO-PHENOXY)-ETHYLCARBAMOYL]-5-PHENYL-ISOXAZOL-3-YL}-PHENYL)-ACETIC+ACID'>GNI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j14 OCA], [http://pdbe.org/2j14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j14 RCSB], [http://www.ebi.ac.uk/pdbsum/2j14 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j14 OCA], [https://pdbe.org/2j14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j14 RCSB], [https://www.ebi.ac.uk/pdbsum/2j14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j14 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/2j14_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/2j14_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j14 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Peroxisome Proliferator-Activated Receptors|Peroxisome Proliferator-Activated Receptors]]
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*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Azimioara, M]]
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[[Category: Large Structures]]
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[[Category: Bursulaya, B]]
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[[Category: Azimioara M]]
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[[Category: Cow, C]]
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[[Category: Bursulaya B]]
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[[Category: Epple, R]]
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[[Category: Cow C]]
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[[Category: Gerken, A]]
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[[Category: Epple R]]
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[[Category: Iskandar, M]]
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[[Category: Gerken A]]
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[[Category: Karanewsky, D]]
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[[Category: Iskandar M]]
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[[Category: Kreusch, A]]
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[[Category: Karanewsky D]]
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[[Category: Russo, R]]
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[[Category: Kreusch A]]
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[[Category: Saez, E]]
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[[Category: Russo R]]
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[[Category: Seidel, H M]]
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[[Category: Saez E]]
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[[Category: Tian, S S]]
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[[Category: Seidel HM]]
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[[Category: Tuntland, T]]
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[[Category: Tian SS]]
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[[Category: Wang, X]]
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[[Category: Tuntland T]]
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[[Category: Wityak, J]]
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[[Category: Wang X]]
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[[Category: Xie, Y]]
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[[Category: Wityak J]]
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[[Category: Activator]]
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[[Category: Xie Y]]
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[[Category: Dna-binding]]
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[[Category: Fatty acid]]
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[[Category: Metal-binding]]
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[[Category: Nuclear protein]]
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[[Category: Nuclear receptor fold]]
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[[Category: Ppar]]
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[[Category: Receptor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc-finger]]
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Current revision

3,4,5-Trisubstituted Isoxazoles as Novel PPARdelta Agonists: Part2

PDB ID 2j14

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