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2j4y

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==Crystal structure of a rhodopsin stabilizing mutant expressed in mammalian cells==
==Crystal structure of a rhodopsin stabilizing mutant expressed in mammalian cells==
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<StructureSection load='2j4y' size='340' side='right' caption='[[2j4y]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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<StructureSection load='2j4y' size='340' side='right'caption='[[2j4y]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2j4y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J4Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2j4y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J4Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1eds|1eds]], [[1edv|1edv]], [[1edw|1edw]], [[1edx|1edx]], [[1f88|1f88]], [[1fdf|1fdf]], [[1gzm|1gzm]], [[1hzx|1hzx]], [[1jfp|1jfp]], [[1l9h|1l9h]], [[1ln6|1ln6]], [[1n3m|1n3m]], [[1nzs|1nzs]], [[1ov0|1ov0]], [[1ov1|1ov1]], [[1u19|1u19]], [[1vqx|1vqx]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4y OCA], [https://pdbe.org/2j4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j4y RCSB], [https://www.ebi.ac.uk/pdbsum/2j4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4y ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4y OCA], [http://pdbe.org/2j4y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j4y RCSB], [http://www.ebi.ac.uk/pdbsum/2j4y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4y ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
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[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Rhodopsin|Rhodopsin]]
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*[[Rhodopsin 3D structures|Rhodopsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bovin]]
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[[Category: Bos taurus]]
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[[Category: Burghammer, M]]
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[[Category: Large Structures]]
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[[Category: Edwards, P C]]
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[[Category: Burghammer M]]
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[[Category: Oprian, D D]]
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[[Category: Edwards PC]]
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[[Category: Schertler, G F.X]]
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[[Category: Oprian DD]]
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[[Category: Standfuss, J]]
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[[Category: Schertler GFX]]
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[[Category: Xie, G]]
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[[Category: Standfuss J]]
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[[Category: Chromophore]]
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[[Category: Xie G]]
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[[Category: G-protein coupled receptor]]
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[[Category: Glycoprotein]]
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[[Category: Integral membrane protein]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Palmitate]]
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[[Category: Phosphorylation]]
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[[Category: Photoreceptor]]
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[[Category: Photoreceptor protein]]
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[[Category: Receptor]]
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[[Category: Retinal protein]]
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[[Category: Sensory transduction]]
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[[Category: Signaling protein]]
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[[Category: Transducer]]
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[[Category: Transmembrane]]
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[[Category: Vision]]
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[[Category: Visual pigment]]
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Current revision

Crystal structure of a rhodopsin stabilizing mutant expressed in mammalian cells

PDB ID 2j4y

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