This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2j67

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:36, 13 December 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
==THE TIR DOMAIN OF HUMAN TOLL-LIKE RECEPTOR 10 (TLR10)==
+
 
-
<StructureSection load='2j67' size='340' side='right' caption='[[2j67]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+
==The TIR domain of human Toll-Like Receptor 10 (TLR10)==
 +
<StructureSection load='2j67' size='340' side='right'caption='[[2j67]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2j67]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The November 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J67 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2j67]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The November 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J67 FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j67 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j67 RCSB], [http://www.ebi.ac.uk/pdbsum/2j67 PDBsum]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j67 OCA], [https://pdbe.org/2j67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j67 RCSB], [https://www.ebi.ac.uk/pdbsum/2j67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j67 ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TLR10_HUMAN TLR10_HUMAN] Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j6/2j67_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j6/2j67_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j67 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 23: Line 27:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 2j67" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Toll-like Receptors|Toll-like Receptors]]
+
*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 31: Line 36:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Toll-like Receptors]]
[[Category: Toll-like Receptors]]
-
[[Category: Arrowsmith, C]]
+
[[Category: Arrowsmith C]]
-
[[Category: Berg, S Van Den]]
+
[[Category: Berglund H]]
-
[[Category: Berglund, H]]
+
[[Category: Busam R]]
-
[[Category: Busam, R]]
+
[[Category: Collins R]]
-
[[Category: Collins, R]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A]]
+
[[Category: Ericsson UB]]
-
[[Category: Ericsson, U B]]
+
[[Category: Flodin S]]
-
[[Category: Flodin, S]]
+
[[Category: Flores A]]
-
[[Category: Flores, A]]
+
[[Category: Graslund S]]
-
[[Category: Graslund, S]]
+
[[Category: Hallberg BM]]
-
[[Category: Hallberg, B M]]
+
[[Category: Hammarstrom M]]
-
[[Category: Hammarstrom, M]]
+
[[Category: Hogbom M]]
-
[[Category: Hogbom, M]]
+
[[Category: Holmberg Schiavone L]]
-
[[Category: Johansson, I]]
+
[[Category: Johansson I]]
-
[[Category: Karlberg, T]]
+
[[Category: Karlberg T]]
-
[[Category: Kotenyova, T]]
+
[[Category: Kotenyova T]]
-
[[Category: Magnusdottir, A]]
+
[[Category: Magnusdottir A]]
-
[[Category: Nilsson, M E]]
+
[[Category: Nilsson ME]]
-
[[Category: Nilsson-Ehle, P]]
+
[[Category: Nilsson-Ehle P]]
-
[[Category: Nordlund, P]]
+
[[Category: Nordlund P]]
-
[[Category: Nyman, T]]
+
[[Category: Nyman T]]
-
[[Category: Ogg, D]]
+
[[Category: Ogg D]]
-
[[Category: Persson, C]]
+
[[Category: Persson C]]
-
[[Category: Sagemark, J]]
+
[[Category: Sagemark J]]
-
[[Category: Schiavone, L Holmberg]]
+
[[Category: Stenmark P]]
-
[[Category: Stenmark, P]]
+
[[Category: Sundstrom M]]
-
[[Category: Sundstrom, M]]
+
[[Category: Thorsell AG]]
-
[[Category: Thorsell, A G]]
+
[[Category: Uppenberg J]]
-
[[Category: Uppenberg, J]]
+
[[Category: Van Den Berg S]]
-
[[Category: Wallden, K]]
+
[[Category: Wallden K]]
-
[[Category: Weigelt, J]]
+
[[Category: Weigelt J]]
-
[[Category: Welin, M]]
+
[[Category: Welin M]]
-
[[Category: Glycoprotein]]
+
-
[[Category: Il-1]]
+
-
[[Category: Immune response]]
+
-
[[Category: Inflammatory response]]
+
-
[[Category: Innate immunity]]
+
-
[[Category: Leucine-rich repeat]]
+
-
[[Category: Membrane]]
+
-
[[Category: Receptor]]
+
-
[[Category: Tir]]
+
-
[[Category: Tlr10]]
+
-
[[Category: Toll]]
+
-
[[Category: Toll-like receptor 10]]
+
-
[[Category: Transmembrane]]
+

Current revision

The TIR domain of human Toll-Like Receptor 10 (TLR10)

PDB ID 2j67

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j67"
Personal tools