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2jam
From Proteopedia
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| - | [[Image:2jam.gif|left|200px]]<br /><applet load="2jam" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2jam, resolution 1.70Å" /> | ||
| - | '''CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE I G'''<br /> | ||
| - | == | + | ==Crystal structure of human calmodulin-dependent protein kinase I G== |
| - | + | <StructureSection load='2jam' size='340' side='right'caption='[[2jam]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[2jam]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAM FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J60:5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>J60</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jam OCA], [https://pdbe.org/2jam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jam RCSB], [https://www.ebi.ac.uk/pdbsum/2jam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jam ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/KCC1G_HUMAN KCC1G_HUMAN] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity). | |
| - | + | == Evolutionary Conservation == | |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [ | + | Check<jmol> |
| - | [ | + | <jmolCheckbox> |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jam_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | + | </jmolCheckbox> | |
| - | [ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jam ConSurf]. |
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| - | + | ==See Also== | |
| + | *[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Unidentified]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bullock A]] | ||
| + | [[Category: Bunkoczi G]] | ||
| + | [[Category: Debreczeni JE]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Keates T]] | ||
| + | [[Category: Knapp S]] | ||
| + | [[Category: Niesen FH]] | ||
| + | [[Category: Pike ACW]] | ||
| + | [[Category: Salah E]] | ||
| + | [[Category: Shrestha L]] | ||
| + | [[Category: Smee C]] | ||
| + | [[Category: Sobott F]] | ||
| + | [[Category: Sundstrom M]] | ||
| + | [[Category: Turnbull A]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of human calmodulin-dependent protein kinase I G
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Categories: Homo sapiens | Large Structures | Unidentified | Arrowsmith CH | Bullock A | Bunkoczi G | Debreczeni JE | Edwards A | Keates T | Knapp S | Niesen FH | Pike ACW | Salah E | Shrestha L | Smee C | Sobott F | Sundstrom M | Turnbull A | Weigelt J | Von Delft F
