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2jc4

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==3'-5' EXONUCLEASE (NEXO) FROM NEISSERIA MENINGITIDIS==
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<StructureSection load='2jc4' size='340' side='right' caption='[[2jc4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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==3'-5' exonuclease (NExo) from Neisseria Meningitidis==
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<StructureSection load='2jc4' size='340' side='right'caption='[[2jc4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jc4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplokokkus_intracellularis_meningitidis"_(sic)_weichselbaum_1887 "diplokokkus intracellularis meningitidis" (sic) weichselbaum 1887]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JC4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jc4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JC4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jc5|2jc5]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_III Exodeoxyribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.2 3.1.11.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jc4 OCA], [https://pdbe.org/2jc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jc4 RCSB], [https://www.ebi.ac.uk/pdbsum/2jc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jc4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jc4 OCA], [http://pdbe.org/2jc4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jc4 RCSB], [http://www.ebi.ac.uk/pdbsum/2jc4 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9K100_NEIMB Q9K100_NEIMB]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jc4_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jc4_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jc4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Exonuclease|Exonuclease]]
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*[[Exonuclease 3D structures|Exonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Exodeoxyribonuclease III]]
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[[Category: Large Structures]]
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[[Category: Adacha, J]]
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[[Category: Neisseria meningitidis]]
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[[Category: Baldwin, G]]
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[[Category: Adacha J]]
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[[Category: Bergeron, J]]
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[[Category: Baldwin G]]
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[[Category: Carpenter, E P]]
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[[Category: Bergeron J]]
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[[Category: Corbett, A]]
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[[Category: Carpenter EP]]
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[[Category: Exley, R]]
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[[Category: Corbett A]]
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[[Category: Freemont, P]]
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[[Category: Exley R]]
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[[Category: Jensen, K]]
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[[Category: Freemont P]]
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[[Category: Kasampalidis, I]]
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[[Category: Jensen K]]
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[[Category: Tang, C]]
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[[Category: Kasampalidis I]]
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[[Category: Thomson, H]]
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[[Category: Tang C]]
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[[Category: Winterbotham, M]]
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[[Category: Thomson H]]
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[[Category: Dna repair]]
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[[Category: Winterbotham M]]
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[[Category: Endonuclease]]
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[[Category: Exonuclease]]
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[[Category: Hydrolase]]
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[[Category: Neisseria meningitidi]]
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[[Category: Repair phosphodiesterase]]
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Current revision

3'-5' exonuclease (NExo) from Neisseria Meningitidis

PDB ID 2jc4

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