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2jc9

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==CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH ADENOSINE==
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<StructureSection load='2jc9' size='340' side='right' caption='[[2jc9]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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==Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with adenosine==
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<StructureSection load='2jc9' size='340' side='right'caption='[[2jc9]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JC9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JC9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j2c|2j2c]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jc9 OCA], [https://pdbe.org/2jc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jc9 RCSB], [https://www.ebi.ac.uk/pdbsum/2jc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jc9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jc9 OCA], [http://pdbe.org/2jc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jc9 RCSB], [http://www.ebi.ac.uk/pdbsum/2jc9 PDBsum]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jc9_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jc9_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jc9 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 5'-nucleotidase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Arrowsmith C]]
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[[Category: Berg, S Van Den]]
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[[Category: Berglund H]]
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[[Category: Berglund, H]]
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[[Category: Busam R]]
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[[Category: Busam, R]]
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[[Category: Collins R]]
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[[Category: Collins, R]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Ehn M]]
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[[Category: Ehn, M]]
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[[Category: Flodin S]]
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[[Category: Flodin, S]]
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[[Category: Flores A]]
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[[Category: Flores, A]]
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[[Category: Graslund S]]
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[[Category: Graslund, S]]
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[[Category: Hallberg BM]]
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[[Category: Hallberg, B M]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M]]
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[[Category: Hogbom M]]
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[[Category: Hogbom, M]]
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[[Category: Holmberg SL]]
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[[Category: Holmberg, S L]]
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[[Category: Karlberg T]]
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[[Category: Karlberg, T]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T]]
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[[Category: Loppnau P]]
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[[Category: Loppnau, P]]
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[[Category: Magnusdottir A]]
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[[Category: Magnusdottir, A]]
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[[Category: Nilsson-Ehle P]]
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[[Category: Nilsson-Ehle, P]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P]]
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[[Category: Nyman T]]
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[[Category: Nyman, T]]
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[[Category: Ogg D]]
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[[Category: Ogg, D]]
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[[Category: Persson C]]
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[[Category: Persson, C]]
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[[Category: Sagemark J]]
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[[Category: Sagemark, J]]
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[[Category: Stenmark P]]
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[[Category: Stenmark, P]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Thorsell AG]]
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[[Category: Thorsell, A G]]
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[[Category: Uppenberg J]]
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[[Category: Uppenberg, J]]
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[[Category: Van Den Berg S]]
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[[Category: Wallden, K]]
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[[Category: Wallden K]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Welin, M]]
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[[Category: Welin M]]
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[[Category: Allosteric enzyme]]
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[[Category: Cn-ii]]
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[[Category: Cytosolic 5-prime nucleotidase ii]]
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[[Category: Cytosolic purine 5-prime nucleotidase]]
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[[Category: Gmp-imp specific nucleotidase]]
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[[Category: High km 5-prime nucleotidase]]
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[[Category: Hydrolase]]
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[[Category: Nt5c2]]
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Current revision

Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with adenosine

PDB ID 2jc9

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