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2jcq

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==The hyaluronan binding domain of murine CD44 in a Type A complex with an HA 8-mer==
==The hyaluronan binding domain of murine CD44 in a Type A complex with an HA 8-mer==
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<StructureSection load='2jcq' size='340' side='right' caption='[[2jcq]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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<StructureSection load='2jcq' size='340' side='right'caption='[[2jcq]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jcq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JCQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jcq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JCQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jcp|2jcp]], [[2jcr|2jcr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcq OCA], [http://pdbe.org/2jcq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jcq RCSB], [http://www.ebi.ac.uk/pdbsum/2jcq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jcq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcq OCA], [https://pdbe.org/2jcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jcq RCSB], [https://www.ebi.ac.uk/pdbsum/2jcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jcq ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD44_MOUSE CD44_MOUSE] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jcq_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jcq_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Banerji, S]]
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[[Category: Mus musculus]]
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[[Category: Campbell, I D]]
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[[Category: Banerji S]]
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[[Category: Day, A J]]
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[[Category: Campbell ID]]
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[[Category: Jackson, D G]]
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[[Category: Day AJ]]
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[[Category: Mahoney, D J]]
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[[Category: Jackson DG]]
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[[Category: Noble, M E.M]]
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[[Category: Mahoney DJ]]
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[[Category: Wright, A J]]
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[[Category: Noble MEM]]
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[[Category: Antigen]]
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[[Category: Wright AJ]]
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[[Category: Blood group antigen]]
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[[Category: C-type lectin]]
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[[Category: Cell adhesion]]
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[[Category: Extracellular matrix]]
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[[Category: Glycoprotein]]
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[[Category: Hyauronan]]
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[[Category: Lectin]]
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[[Category: Link-domain]]
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[[Category: Membrane]]
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[[Category: Phosphorylation]]
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[[Category: Proteoglycan]]
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[[Category: Pyrrolidone carboxylic acid]]
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[[Category: Receptor]]
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[[Category: Sugar- binding]]
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[[Category: Sugar-binding protein]]
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[[Category: Sulfation]]
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[[Category: Transmembrane]]
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Current revision

The hyaluronan binding domain of murine CD44 in a Type A complex with an HA 8-mer

PDB ID 2jcq

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