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2je5

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==STRUCTURAL AND MECHANISTIC BASIS OF PENICILLIN BINDING PROTEIN INHIBITION BY LACTIVICINS==
==STRUCTURAL AND MECHANISTIC BASIS OF PENICILLIN BINDING PROTEIN INHIBITION BY LACTIVICINS==
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<StructureSection load='2je5' size='340' side='right' caption='[[2je5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='2je5' size='340' side='right'caption='[[2je5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2je5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JE5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2je5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JE5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=L4C:(2E)-2-{[(2S)-2-(ACETYLAMINO)-2-CARBOXYETHOXY]IMINO}PENTANEDIOIC+ACID'>L4C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bg1|2bg1]], [[2bg3|2bg3]], [[2bg4|2bg4]], [[2fff|2fff]], [[2jch|2jch]], [[2jci|2jci]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=L4C:(2E)-2-{[(2S)-2-(ACETYLAMINO)-2-CARBOXYETHOXY]IMINO}PENTANEDIOIC+ACID'>L4C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2je5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2je5 OCA], [http://pdbe.org/2je5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2je5 RCSB], [http://www.ebi.ac.uk/pdbsum/2je5 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2je5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2je5 OCA], [https://pdbe.org/2je5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2je5 RCSB], [https://www.ebi.ac.uk/pdbsum/2je5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2je5 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O70038_STREE O70038_STREE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2je5_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2je5_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Penicillin-binding protein|Penicillin-binding protein]]
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*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Strr6]]
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[[Category: Large Structures]]
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[[Category: Brown, T J]]
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[[Category: Streptococcus pneumoniae R6]]
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[[Category: Dessen, A]]
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[[Category: Brown TJ]]
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[[Category: Fisher, D S]]
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[[Category: Dessen A]]
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[[Category: Joris, B]]
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[[Category: Fisher DS]]
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[[Category: Luxen, A]]
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[[Category: Joris B]]
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[[Category: Macheboeuf, P]]
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[[Category: Luxen A]]
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[[Category: Schofield, C J]]
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[[Category: Macheboeuf P]]
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[[Category: Zervosen, A]]
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[[Category: Schofield CJ]]
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[[Category: Cell wall]]
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[[Category: Zervosen A]]
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[[Category: Drug-binding protein]]
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[[Category: Gamma lactam antibiotic]]
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[[Category: Peptidoglycan]]
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[[Category: Peptidoglycan synthesis multifunctional enzyme]]
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Current revision

STRUCTURAL AND MECHANISTIC BASIS OF PENICILLIN BINDING PROTEIN INHIBITION BY LACTIVICINS

PDB ID 2je5

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