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2jfk

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[[Image:2jfk.gif|left|200px]]
 
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{{Structure
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==Structure of the MAT domain of human FAS with malonyl-CoA==
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|PDB= 2jfk |SIZE=350|CAPTION= <scene name='initialview01'>2jfk</scene>, resolution 2.40&Aring;
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<StructureSection load='2jfk' size='340' side='right'caption='[[2jfk]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Coa+Binding+Site+For+Chain+D'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=COA:COENZYME A'>COA</scene>
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<table><tr><td colspan='2'>[[2jfk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JFK FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Fatty-acid_synthase Fatty-acid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.85 2.3.1.85]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MCS:MALONYL+CYSTEINE'>MCS</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfk OCA], [https://pdbe.org/2jfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jfk RCSB], [https://www.ebi.ac.uk/pdbsum/2jfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jfk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FAS_HUMAN FAS_HUMAN] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/2jfk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jfk ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF THE MAT DOMAIN OF HUMAN FAS WITH MALONYL-COA'''
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==See Also==
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*[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]]
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__TOC__
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==Disease==
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</StructureSection>
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Known diseases associated with this structure: Autoimmune lymphoproliferative syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=134637 134637]], Autoimmune lymphoproliferative syndrome, type IA OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=134637 134637]], Squamous cell carcinoma, burn scar-related, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=134637 134637]]
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==About this Structure==
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2JFK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFK OCA].
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[[Category: Fatty-acid synthase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi G]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Hozjan, V.]]
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[[Category: Hozjan V]]
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[[Category: Kavanagh, K.]]
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[[Category: Kavanagh K]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Rojkova, A.]]
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[[Category: Rojkova A]]
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[[Category: Smith, S.]]
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[[Category: Smith S]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Watt, S.]]
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[[Category: Watt S]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Wu, X.]]
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[[Category: Wu X]]
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[[Category: COA]]
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[[Category: acetyl transferase]]
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[[Category: acetylation]]
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[[Category: fatty acid biosynthesis]]
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[[Category: fatty acid synthase]]
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[[Category: hydrolase]]
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[[Category: lipid synthesis]]
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[[Category: lyase]]
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[[Category: malonyl transferase]]
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[[Category: malonylation]]
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[[Category: mat domain]]
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[[Category: multifunctional enzyme]]
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[[Category: nad]]
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[[Category: nadp]]
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[[Category: oxidoreductase]]
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[[Category: phosphopantetheine]]
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[[Category: phosphorylation]]
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[[Category: pyridoxal phosphate]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:41:14 2008''
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Current revision

Structure of the MAT domain of human FAS with malonyl-CoA

PDB ID 2jfk

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