This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2jfl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:46, 13 December 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='2jfl' size='340' side='right'caption='[[2jfl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2jfl' size='340' side='right'caption='[[2jfl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2jfl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JFL FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2jfl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JFL FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DKI:5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE'>DKI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j51|2j51]], [[2ja0|2ja0]], [[2jfm|2jfm]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfl OCA], [https://pdbe.org/2jfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jfl RCSB], [https://www.ebi.ac.uk/pdbsum/2jfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jfl ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfl OCA], [http://pdbe.org/2jfl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jfl RCSB], [http://www.ebi.ac.uk/pdbsum/2jfl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jfl ProSAT]</span></td></tr>
+
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SLK_HUMAN SLK_HUMAN] Mediates apoptosis and actin stress fiber dissolution.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 33: Line 33:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Non-specific serine/threonine protein kinase]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Bunkoczi G]]
-
[[Category: Bunkoczi, G]]
+
[[Category: Edwards A]]
-
[[Category: Delft, F von]]
+
[[Category: Fedorov O]]
-
[[Category: Edwards, A]]
+
[[Category: Keates T]]
-
[[Category: Fedorov, O]]
+
[[Category: Knapp S]]
-
[[Category: Keates, T]]
+
[[Category: Papagrigoriou E]]
-
[[Category: Knapp, S]]
+
[[Category: Pike ACW]]
-
[[Category: Papagrigoriou, E]]
+
[[Category: Rellos P]]
-
[[Category: Pike, A C.W]]
+
[[Category: Salah E]]
-
[[Category: Rellos, P]]
+
[[Category: Savitsky P]]
-
[[Category: Salah, E]]
+
[[Category: Sundstrom M]]
-
[[Category: Savitsky, P]]
+
[[Category: Weigelt J]]
-
[[Category: Sundstrom, M]]
+
[[Category: Von Delft F]]
-
[[Category: Weigelt, J]]
+
-
[[Category: Apoptosis]]
+
-
[[Category: Atp-binding]]
+
-
[[Category: Germinal centre kinase]]
+
-
[[Category: Kinase]]
+
-
[[Category: Muscle development]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Phosphorylation]]
+
-
[[Category: Serine- threonine kinase 2]]
+
-
[[Category: Serine-threonine-protein kinase]]
+
-
[[Category: Serine/threonine-protein kinase]]
+
-
[[Category: Transferase]]
+

Current revision

CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE

PDB ID 2jfl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jfl"
Personal tools