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2jga

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==CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE III IN COMPLEX WITH PHOSPHATE AND MAGNESIUM==
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<StructureSection load='2jga' size='340' side='right' caption='[[2jga]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
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==Crystal structure of human cytosolic 5'-nucleotidase III in complex with phosphate and magnesium==
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<StructureSection load='2jga' size='340' side='right'caption='[[2jga]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jga]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jga]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JGA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cn1|2cn1]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jga OCA], [https://pdbe.org/2jga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jga RCSB], [https://www.ebi.ac.uk/pdbsum/2jga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jga ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jga OCA], [http://pdbe.org/2jga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jga RCSB], [http://www.ebi.ac.uk/pdbsum/2jga PDBsum]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/5NT3A_HUMAN 5NT3A_HUMAN] Hemolytic anemia due to pyrimidine 5' nucleotidase deficiency. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/5NT3A_HUMAN 5NT3A_HUMAN] Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458).<ref>PMID:15968458</ref> <ref>PMID:24603684</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jga_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jga_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jga ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 5'-nucleotidase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Arrowsmith C]]
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[[Category: Berg, S Van Den]]
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[[Category: Berglund H]]
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[[Category: Berglund, H]]
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[[Category: Collins R]]
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[[Category: Collins, R]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Ehn M]]
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[[Category: Ehn, M]]
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[[Category: Flodin S]]
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[[Category: Flodin, S]]
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[[Category: Flores A]]
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[[Category: Flores, A]]
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[[Category: Graslund S]]
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[[Category: Graslund, S]]
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[[Category: Hallberg M]]
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[[Category: Hallberg, M]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M]]
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[[Category: Hogbom M]]
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[[Category: Hogbom, M]]
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[[Category: Holmberg B]]
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[[Category: Holmberg, B]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T]]
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[[Category: Magnusdottir A]]
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[[Category: Magnusdottir, A]]
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[[Category: Nilsson-Ehle P]]
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[[Category: Nilsson-Ehle, P]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P]]
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[[Category: Nyman T]]
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[[Category: Nyman, T]]
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[[Category: Ogg D]]
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[[Category: Ogg, D]]
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[[Category: Persson C]]
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[[Category: Persson, C]]
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[[Category: Sagemark J]]
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[[Category: Sagemark, J]]
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[[Category: Schiavone L]]
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[[Category: Schiavone, L]]
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[[Category: Stenmark P]]
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[[Category: Stenmark, P]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Thorsell AG]]
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[[Category: Thorsell, A G]]
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[[Category: Uppenberg J]]
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[[Category: Uppenberg, J]]
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[[Category: Van Den Berg S]]
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[[Category: Wallden, K]]
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[[Category: Wallden K]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Welin, M]]
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[[Category: Welin M]]
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[[Category: 5-prime]]
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[[Category: Cytosolic iii]]
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[[Category: Disease mutation]]
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[[Category: Hydrolase]]
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[[Category: Nucleotidase]]
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[[Category: Nucleotide metabolism]]
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[[Category: Nucleotide-binding]]
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[[Category: P5n1]]
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[[Category: Pyrimidine 5-prime nucleotidase deficiency]]
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[[Category: Pyrimidine 5-prime- nucleotidase 1]]
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[[Category: Umph1]]
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[[Category: Uridine 5-prime monophosphate hydrolase 1]]
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Current revision

Crystal structure of human cytosolic 5'-nucleotidase III in complex with phosphate and magnesium

PDB ID 2jga

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