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2jkx

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==GALACTOSE OXIDASE. MATGO. COPPER FREE, EXPRESSED IN PICHIA PASTORIS.==
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<StructureSection load='2jkx' size='340' side='right' caption='[[2jkx]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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==Galactose oxidase. MatGO. Copper free, expressed in Pichia Pastoris.==
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<StructureSection load='2jkx' size='340' side='right'caption='[[2jkx]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jkx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusarium_graminearum Fusarium graminearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JKX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jkx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_graminearum Fusarium graminearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JKX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1t2x|1t2x]], [[1goh|1goh]], [[2vz3|2vz3]], [[1gof|1gof]], [[2vz1|2vz1]], [[1k3i|1k3i]], [[1gog|1gog]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Galactose_oxidase Galactose oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.9 1.1.3.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jkx OCA], [https://pdbe.org/2jkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jkx RCSB], [https://www.ebi.ac.uk/pdbsum/2jkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jkx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jkx OCA], [http://pdbe.org/2jkx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jkx RCSB], [http://www.ebi.ac.uk/pdbsum/2jkx PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GAOA_GIBZE GAOA_GIBZE]] Catalyzes the sterospecific oxidation of primary alcohols to the corresponding aldehydes. The biologically relevant substrate of the enzyme is not known as the enzyme exhibits broad substrate specificity from small alcohols through sugars to oligo- and polysaccharides (By similarity).
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[https://www.uniprot.org/uniprot/GAOA_GIBZA GAOA_GIBZA] Catalyzes the sterospecific oxidation of primary alcohols to the corresponding aldehydes. The biologically relevant substrate of the enzyme is not known as the enzyme exhibits broad substrate specificity from small alcohols through sugars to oligo- and polysaccharides.<ref>PMID:13641238</ref> <ref>PMID:4441089</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jkx_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jkx_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jkx ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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</StructureSection>
</StructureSection>
[[Category: Fusarium graminearum]]
[[Category: Fusarium graminearum]]
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[[Category: Galactose oxidase]]
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[[Category: Large Structures]]
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[[Category: Deacon, S E]]
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[[Category: Deacon SE]]
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[[Category: Firbank, S J]]
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[[Category: Firbank SJ]]
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[[Category: Knowles, P F]]
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[[Category: Knowles PF]]
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[[Category: Mahmoud, K]]
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[[Category: Mahmoud K]]
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[[Category: McPherson, M J]]
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[[Category: McPherson MJ]]
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[[Category: Phillips, S E.V]]
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[[Category: Phillips SEV]]
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[[Category: Spooner, R K]]
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[[Category: Spooner RK]]
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[[Category: Copper enzyme]]
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[[Category: Enzyme catalysis]]
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[[Category: Kelch repeat]]
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[[Category: Metal-binding]]
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[[Category: Oxidase]]
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[[Category: Oxidoreductase]]
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[[Category: Protein engineering]]
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[[Category: Secreted]]
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[[Category: Thioether bond]]
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Current revision

Galactose oxidase. MatGO. Copper free, expressed in Pichia Pastoris.

PDB ID 2jkx

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