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2uv1

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==HEXAGONAL CRYSTAL FORM OF GAMS FROM BACTERIOPHAGE LAMBDA.==
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<StructureSection load='2uv1' size='340' side='right' caption='[[2uv1]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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==Hexagonal crystal form of GamS from bacteriophage lambda.==
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<StructureSection load='2uv1' size='340' side='right'caption='[[2uv1]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2uv1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UV1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2uv1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UV1 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uuz|2uuz]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uv1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uv1 RCSB], [http://www.ebi.ac.uk/pdbsum/2uv1 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uv1 OCA], [https://pdbe.org/2uv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uv1 RCSB], [https://www.ebi.ac.uk/pdbsum/2uv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uv1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VGAM_LAMBD VGAM_LAMBD]] Gene GAM protein inhibits the host recBC-coded nuclease and thus promotes the late, rolling-circle mode of lambda DNA replication.
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[https://www.uniprot.org/uniprot/GAM_LAMBD GAM_LAMBD] Binds to host RecBCD nuclease and inhibits it thereby protecting the viral DNA against recBCD mediated degradation.<ref>PMID:17544443</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uv1_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uv1_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uv1 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2uv1" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Enterobacteria phage lambda]]
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[[Category: Escherichia virus Lambda]]
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[[Category: Cook, N]]
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[[Category: Large Structures]]
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[[Category: Court, R I]]
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[[Category: Cook N]]
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[[Category: Saikrishnan, K]]
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[[Category: Court RI]]
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[[Category: Wigley, D B]]
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[[Category: Saikrishnan K]]
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[[Category: Bacteriophage lambda]]
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[[Category: Wigley DB]]
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[[Category: Inhibitor]]
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[[Category: Nuclease inhibitor recbcd inhibitor]]
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[[Category: Putative dna mimetic]]
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Current revision

Hexagonal crystal form of GamS from bacteriophage lambda.

PDB ID 2uv1

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OCA

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