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2uvq

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[[Image:2uvq.gif|left|200px]]
 
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{{Structure
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==Crystal structure of human uridine-cytidine kinase 1 in complex with ADP==
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|PDB= 2uvq |SIZE=350|CAPTION= <scene name='initialview01'>2uvq</scene>, resolution 3.00&Aring;
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<StructureSection load='2uvq' size='340' side='right'caption='[[2uvq]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>
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<table><tr><td colspan='2'>[[2uvq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UVQ FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Uridine_kinase Uridine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.48 2.7.1.48]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvq OCA], [https://pdbe.org/2uvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uvq RCSB], [https://www.ebi.ac.uk/pdbsum/2uvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uvq ProSAT]</span></td></tr>
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</table>
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'''CRYSTAL STRUCTURE OF HUMAN URIDINE-CYTIDINE KINASE 1 IN COMPLEX WITH ADP'''
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== Function ==
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[https://www.uniprot.org/uniprot/UCK1_HUMAN UCK1_HUMAN] Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702).<ref>PMID:11306702</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2UVQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVQ OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uvq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uvq ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Uridine kinase]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Berglund H]]
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[[Category: Berg, S Van Den.]]
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[[Category: Busam R]]
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[[Category: Berglund, H.]]
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[[Category: Collins R]]
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[[Category: Busam, R.]]
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[[Category: Edwards A]]
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[[Category: Collins, R.]]
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[[Category: Ericsson UB]]
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[[Category: Edwards, A.]]
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[[Category: Flodin S]]
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[[Category: Ericsson, U B.]]
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[[Category: Flores A]]
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[[Category: Flodin, S.]]
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[[Category: Graslund S]]
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[[Category: Flores, A.]]
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[[Category: Hallberg BM]]
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[[Category: Graslund, S.]]
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[[Category: Hammarstrom M]]
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[[Category: Hallberg, B M.]]
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[[Category: Hogbom M]]
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[[Category: Hammarstrom, M.]]
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[[Category: Holmberg Schiavone L]]
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[[Category: Hogbom, M.]]
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[[Category: Johansson I]]
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[[Category: Johansson, I.]]
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[[Category: Karlberg T]]
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[[Category: Karlberg, T.]]
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[[Category: Kosinska U]]
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[[Category: Kosinska, U.]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T.]]
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[[Category: Moche M]]
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[[Category: Moche, M.]]
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[[Category: Nilsson MEP]]
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[[Category: Nilsson, M E.P.]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P.]]
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[[Category: Nyman T]]
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[[Category: Nyman, T.]]
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[[Category: Ogg D]]
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[[Category: Ogg, D.]]
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[[Category: Persson C]]
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[[Category: Persson, C.]]
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[[Category: Sagemark J]]
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[[Category: Sagemark, J.]]
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[[Category: Stenmark P]]
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[[Category: Schiavone, L Holmberg.]]
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[[Category: Sundstrom M]]
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[[Category: Stenmark, P.]]
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[[Category: Thorsell AG]]
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[[Category: Sundstrom, M.]]
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[[Category: Uppenberg J]]
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[[Category: Thorsell, A G.]]
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[[Category: Uppsten M]]
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[[Category: Uppenberg, J.]]
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[[Category: Van Den Berg S]]
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[[Category: Uppsten, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Welin M]]
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[[Category: Welin, M.]]
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[[Category: ADP]]
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[[Category: atp-binding]]
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[[Category: kinase]]
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[[Category: nucleoside kinase]]
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[[Category: nucleotide-binding]]
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[[Category: transferase]]
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[[Category: uck]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:51:17 2008''
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Current revision

Crystal structure of human uridine-cytidine kinase 1 in complex with ADP

PDB ID 2uvq

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