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2uz4

From Proteopedia

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{{Seed}}
 
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[[Image:2uz4.png|left|200px]]
 
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==HhaI DNA methyltransferase R165N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH==
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The line below this paragraph, containing "STRUCTURE_2uz4", creates the "Structure Box" on the page.
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<StructureSection load='2uz4' size='340' side='right'caption='[[2uz4]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2uz4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_parahaemolyticus Haemophilus parahaemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZ4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2uz4| PDB=2uz4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz4 OCA], [https://pdbe.org/2uz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uz4 RCSB], [https://www.ebi.ac.uk/pdbsum/2uz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uz4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uz4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uz4 ConSurf].
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<div style="clear:both"></div>
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===HHAI DNA METHYLTRANSFERASE R165N MUTANT COMPLEX WITH 13MER GCGC-GMGC OLIGONUCLEOTIDE AND SAH===
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==See Also==
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2UZ4 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Haemophilus_parahaemolyticus Haemophilus parahaemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ4 OCA].
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[[Category: Haemophilus parahaemolyticus]]
[[Category: Haemophilus parahaemolyticus]]
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[[Category: Daujotyte, D.]]
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[[Category: Large Structures]]
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[[Category: Grazulis, S.]]
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[[Category: Daujotyte D]]
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[[Category: Leinartaite, L.]]
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[[Category: Grazulis S]]
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[[Category: Base flipping]]
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[[Category: Leinartaite L]]
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[[Category: Dna methyltransferase]]
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[[Category: Methyltransferase]]
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[[Category: Restriction system]]
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[[Category: S-adenosyl-l-methionine]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:30:21 2009''
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Current revision

HhaI DNA methyltransferase R165N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH

PDB ID 2uz4

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