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2v20

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==STRUCTURE OF A TEM-1 BETA-LACTAMASE INSERTANT ALLOSTERICALLY REGULATED BY KANAMYCIN AND ANIONS. COMPLEX WITH SULFATE.==
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<StructureSection load='2v20' size='340' side='right' caption='[[2v20]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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==Structure of a TEM-1 beta-lactamase insertant allosterically regulated by kanamycin and anions. Complex with sulfate.==
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<StructureSection load='2v20' size='340' side='right'caption='[[2v20]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2v20]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V20 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2v20]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V20 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1axb|1axb]], [[1bt5|1bt5]], [[1btl|1btl]], [[1ck3|1ck3]], [[1erm|1erm]], [[1ero|1ero]], [[1erq|1erq]], [[1esu|1esu]], [[1fqg|1fqg]], [[1jtd|1jtd]], [[1jtg|1jtg]], [[1jvj|1jvj]], [[1jwp|1jwp]], [[1jwv|1jwv]], [[1jwz|1jwz]], [[1lhy|1lhy]], [[1li0|1li0]], [[1li9|1li9]], [[1m40|1m40]], [[1nxy|1nxy]], [[1ny0|1ny0]], [[1nym|1nym]], [[1nyy|1nyy]], [[1pzo|1pzo]], [[1pzp|1pzp]], [[1s0w|1s0w]], [[1tem|1tem]], [[1xpb|1xpb]], [[1xxm|1xxm]], [[1yt4|1yt4]], [[1zg4|1zg4]], [[1zg6|1zg6]], [[2v1z|2v1z]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v20 OCA], [https://pdbe.org/2v20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v20 RCSB], [https://www.ebi.ac.uk/pdbsum/2v20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v20 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v20 OCA], [http://pdbe.org/2v20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v20 RCSB], [http://www.ebi.ac.uk/pdbsum/2v20 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
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[https://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v20_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v20_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
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[[Category: Barrios, H]]
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[[Category: Barrios H]]
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[[Category: Declercq, J P]]
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[[Category: Declercq JP]]
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[[Category: Evrard, C]]
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[[Category: Evrard C]]
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[[Category: Fastrez, J]]
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[[Category: Fastrez J]]
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[[Category: Mathonet, P]]
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[[Category: Mathonet P]]
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[[Category: Soumillion, P]]
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[[Category: Soumillion P]]
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[[Category: Allosteric regulation]]
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[[Category: Antibiotic resistance]]
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[[Category: Hydrolase]]
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[[Category: Insertion mutant]]
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Current revision

Structure of a TEM-1 beta-lactamase insertant allosterically regulated by kanamycin and anions. Complex with sulfate.

PDB ID 2v20

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