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2v26

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==MYOSIN VI (MD) PRE-POWERSTROKE STATE (MG.ADP.VO4)==
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==Myosin VI (MD) pre-powerstroke state (Mg.ADP.VO4)==
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<StructureSection load='2v26' size='340' side='right' caption='[[2v26]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='2v26' size='340' side='right'caption='[[2v26]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2v26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V26 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2v26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V26 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bkh|2bkh]], [[2bki|2bki]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v26 OCA], [http://pdbe.org/2v26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v26 RCSB], [http://www.ebi.ac.uk/pdbsum/2v26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v26 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v26 OCA], [https://pdbe.org/2v26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v26 RCSB], [https://www.ebi.ac.uk/pdbsum/2v26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v26 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref>
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[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v26_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v26_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Myosin|Myosin]]
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*[[Myosin 3D Structures|Myosin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pig]]
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[[Category: Large Structures]]
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[[Category: Houdusse, A]]
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[[Category: Sus scrofa]]
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[[Category: Llinas, P]]
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[[Category: Houdusse A]]
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[[Category: Menetrey, J]]
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[[Category: Llinas P]]
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[[Category: Mukherjea, M]]
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[[Category: Menetrey J]]
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[[Category: Sweeney, H L]]
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[[Category: Mukherjea M]]
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[[Category: Actin-binding]]
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[[Category: Sweeney HL]]
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[[Category: Atp-binding]]
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[[Category: Calmodulin-binding]]
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[[Category: Domain motor]]
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[[Category: Endocytosis]]
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[[Category: Golgi apparatus]]
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[[Category: Membrane]]
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[[Category: Molecular motor]]
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[[Category: Motor protein]]
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[[Category: Myosin]]
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[[Category: Myosin vi]]
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[[Category: Nuclear protein]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphorylation]]
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[[Category: Pre- powerstroke]]
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[[Category: Protein transport]]
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[[Category: Structural protein]]
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[[Category: Transition state]]
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[[Category: Transport]]
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[[Category: Vanadate]]
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Current revision

Myosin VI (MD) pre-powerstroke state (Mg.ADP.VO4)

PDB ID 2v26

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