2v3c

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[[Image:2v3c.png|left|200px]]
 
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==Crystal structure of the SRP54-SRP19-7S.S SRP RNA complex of M. jannaschii==
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The line below this paragraph, containing "STRUCTURE_2v3c", creates the "Structure Box" on the page.
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<StructureSection load='2v3c' size='340' side='right'caption='[[2v3c]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2v3c]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V3C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v3c OCA], [https://pdbe.org/2v3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v3c RCSB], [https://www.ebi.ac.uk/pdbsum/2v3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v3c ProSAT]</span></td></tr>
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{{STRUCTURE_2v3c| PDB=2v3c | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SRP19_METJA SRP19_METJA] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v3/2v3c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v3c ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The signal-recognition particle (SRP) is a ubiquitous protein-RNA complex that targets proteins to cellular membranes for insertion or secretion. A key player in SRP-mediated protein targeting is the evolutionarily conserved core consisting of the SRP RNA and the multidomain protein SRP54. Communication between the SRP54 domains is critical for SRP function, where signal sequence binding at the M domain directs receptor binding at the GTPase domain (NG domain). These SRP activities are linked to domain rearrangements, for which the role of SRP RNA is not clear. In free SRP, a direct interaction of the GTPase domain with SRP RNA has been proposed but has never been structurally verified. In this study, we present the crystal structure at 2.5-A resolution of the SRP54-SRP19-SRP RNA complex of Methanococcus jannaschii SRP. The structure reveals an RNA-bound conformation of the SRP54 GTPase domain, in which the domain is spatially well separated from the signal peptide binding site. The association of both the N and G domains with SRP RNA in free SRP provides further structural evidence for the pivotal role of SRP RNA in the regulation of the SRP54 activity.
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===CRYSTAL STRUCTURE OF THE SRP54-SRP19-7S.S SRP RNA COMPLEX OF M. JANNASCHII===
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Interaction of signal-recognition particle 54 GTPase domain and signal-recognition particle RNA in the free signal-recognition particle.,Hainzl T, Huang S, Sauer-Eriksson AE Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14911-6. Epub 2007 Sep 10. PMID:17846429<ref>PMID:17846429</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2v3c" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17846429}}, adds the Publication Abstract to the page
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*[[Signal recognition particle 3D structures|Signal recognition particle 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17846429 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17846429}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2V3C is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V3C OCA].
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==Reference==
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<ref group="xtra">PMID:17846429</ref><references group="xtra"/>
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[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Hainzl, T.]]
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[[Category: Hainzl T]]
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[[Category: Huang, S.]]
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[[Category: Huang S]]
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[[Category: Sauer-Eriksson, A E.]]
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[[Category: Sauer-Eriksson AE]]
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[[Category: Gtp-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Ribonucleoprotein]]
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[[Category: Rna]]
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[[Category: Rna-binding]]
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[[Category: Signal recognition particle]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:41:54 2010''
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Current revision

Crystal structure of the SRP54-SRP19-7S.S SRP RNA complex of M. jannaschii

PDB ID 2v3c

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OCA

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