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2v4i

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{{Seed}}
 
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[[Image:2v4i.jpg|left|200px]]
 
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<!--
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==Structure of a novel N-acyl-enzyme intermediate of an N-terminal nucleophile (Ntn) hydrolase, OAT2==
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The line below this paragraph, containing "STRUCTURE_2v4i", creates the "Structure Box" on the page.
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<StructureSection load='2v4i' size='340' side='right'caption='[[2v4i]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2v4i]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_clavuligerus Streptomyces clavuligerus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYA:N-ACETYLALANINE'>AYA</scene></td></tr>
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{{STRUCTURE_2v4i| PDB=2v4i | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4i OCA], [https://pdbe.org/2v4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4i RCSB], [https://www.ebi.ac.uk/pdbsum/2v4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4i ProSAT]</span></td></tr>
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</table>
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===STRUCTURE OF A NOVEL N-ACYL-ENZYME INTERMEDIATE OF AN N-TERMINAL NUCLEOPHILE (NTN) HYDROLASE, OAT2===
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== Function ==
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[https://www.uniprot.org/uniprot/GNAT2_STRCL GNAT2_STRCL] Catalyzes the biosynthesis of ornithine by transacetylation between N(2)-acetylornithine and glutamate. It can also use L-arginine, L-glutamine and L-lysine as acetyl acceptors.<ref>PMID:11985581</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15352873 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v4i_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15352873}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2V4I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_clavuligerus Streptomyces clavuligerus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4I OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v4i ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster., Elkins JM, Kershaw NJ, Schofield CJ, Biochem J. 2005 Jan 15;385(Pt 2):565-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15352873 15352873]
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<references/>
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[[Category: Glutamate N-acetyltransferase]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces clavuligerus]]
[[Category: Streptomyces clavuligerus]]
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[[Category: Clifton, I J.]]
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[[Category: Clifton IJ]]
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[[Category: Iqbal, A.]]
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[[Category: Iqbal A]]
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[[Category: Schofield, C J.]]
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[[Category: Schofield CJ]]
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[[Category: Acyl enzyme]]
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[[Category: Acyltransferase]]
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[[Category: Cytoplasm]]
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[[Category: Ntn hydrolase]]
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[[Category: Ornithine acetyl transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 8 09:23:36 2008''
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Current revision

Structure of a novel N-acyl-enzyme intermediate of an N-terminal nucleophile (Ntn) hydrolase, OAT2

PDB ID 2v4i

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