2v4m
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2v4m is ON HOLD until sometime in the future Authors: MOCHE, M., LEHTIO, L., ANDERSSON, J., ARROWSMITH, C.H., BERGLUND, H., COLLINS, R., DAHLGREN, L...) |
|||
| (11 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | The | + | ==The isomerase domain of human glutamine-fructose-6-phosphate transaminase 1 (GFPT1) in complex with fructose 6-phosphate== |
| - | + | <StructureSection load='2v4m' size='340' side='right'caption='[[2v4m]], [[Resolution|resolution]] 2.29Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2v4m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=F6R:FRUCTOSE+-6-PHOSPHATE'>F6R</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4m OCA], [https://pdbe.org/2v4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4m RCSB], [https://www.ebi.ac.uk/pdbsum/2v4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4m ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/GFPT1_HUMAN GFPT1_HUMAN] Defects in GFPT1 are the cause of myasthenia, congenital, with tubular aggregates, type 1 (CMSTA1) [MIM:[https://omim.org/entry/610542 610542]. A congenital myasthenic syndrome characterized by onset of proximal muscle weakness in the first decade. Individuals with this condition have a recognizable pattern of weakness of shoulder and pelvic girdle muscles, and sparing of ocular or facial muscles. EMG classically shows a decremental response to repeated nerve stimulation, a sign of neuromuscular junction dysfunction. Affected individuals show a favorable response to acetylcholinesterase (AChE) inhibitors.<ref>PMID:21310273</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GFPT1_HUMAN GFPT1_HUMAN] Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v4m_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v4m ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Andersson J]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Berglund H]] | ||
| + | [[Category: Collins R]] | ||
| + | [[Category: Dahlgren LG]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Flodin S]] | ||
| + | [[Category: Flores A]] | ||
| + | [[Category: Graslund S]] | ||
| + | [[Category: Hammarstrom M]] | ||
| + | [[Category: Johansson A]] | ||
| + | [[Category: Johansson I]] | ||
| + | [[Category: Karlberg T]] | ||
| + | [[Category: Kotenyova T]] | ||
| + | [[Category: Lehtio L]] | ||
| + | [[Category: Moche M]] | ||
| + | [[Category: Nilsson ME]] | ||
| + | [[Category: Nordlund P]] | ||
| + | [[Category: Nyman T]] | ||
| + | [[Category: Persson C]] | ||
| + | [[Category: Sagemark J]] | ||
| + | [[Category: Schueler H]] | ||
| + | [[Category: Svensson S]] | ||
| + | [[Category: Thorsell AG]] | ||
| + | [[Category: Tresaugues L]] | ||
| + | [[Category: Uppenberg J]] | ||
| + | [[Category: Van Den Berg S]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Welin M]] | ||
| + | [[Category: Wikstrom M]] | ||
| + | [[Category: Wisniewska M]] | ||
Current revision
The isomerase domain of human glutamine-fructose-6-phosphate transaminase 1 (GFPT1) in complex with fructose 6-phosphate
| |||||||||||
Categories: Homo sapiens | Large Structures | Andersson J | Arrowsmith CH | Berglund H | Collins R | Dahlgren LG | Edwards AM | Flodin S | Flores A | Graslund S | Hammarstrom M | Johansson A | Johansson I | Karlberg T | Kotenyova T | Lehtio L | Moche M | Nilsson ME | Nordlund P | Nyman T | Persson C | Sagemark J | Schueler H | Svensson S | Thorsell AG | Tresaugues L | Uppenberg J | Van Den Berg S | Weigelt J | Welin M | Wikstrom M | Wisniewska M
