2v4u

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[[Image:2v4u.jpg|left|200px]]
 
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==Human CTP synthetase 2 - glutaminase domain in complex with 5-OXO-L- NORLEUCINE==
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The line below this paragraph, containing "STRUCTURE_2v4u", creates the "Structure Box" on the page.
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<StructureSection load='2v4u' size='340' side='right'caption='[[2v4u]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2v4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYD:2-AMINO-6-(CYSTEIN-S-YL)-5-OXO-HEXANOIC+ACID'>CYD</scene></td></tr>
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{{STRUCTURE_2v4u| PDB=2v4u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4u OCA], [https://pdbe.org/2v4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4u RCSB], [https://www.ebi.ac.uk/pdbsum/2v4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4u ProSAT]</span></td></tr>
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</table>
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===HUMAN CTP SYNTHETASE 2 - GLUTAMINASE DOMAIN IN COMPLEX WITH 5-OXO-L-NORLEUCINE===
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== Function ==
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[https://www.uniprot.org/uniprot/PYRG2_HUMAN PYRG2_HUMAN] Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.<ref>PMID:10899599</ref> <ref>PMID:16179339</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2V4U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4U OCA].
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Check<jmol>
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[[Category: CTP synthase]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v4u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v4u ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Andersson, J.]]
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[[Category: Andersson J]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berg, S Van Den.]]
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[[Category: Berglund H]]
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[[Category: Berglund, H.]]
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[[Category: Collins R]]
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[[Category: Collins, R.]]
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[[Category: Dahlgren LG]]
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[[Category: Dahlgren, L G.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Flodin S]]
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[[Category: Flodin, S.]]
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[[Category: Flores A]]
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[[Category: Flores, A.]]
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[[Category: Graslund S]]
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[[Category: Graslund, S.]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M.]]
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[[Category: Johansson A]]
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[[Category: Johansson, A.]]
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[[Category: Johansson I]]
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[[Category: Johansson, I.]]
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[[Category: Karlberg T]]
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[[Category: Karlberg, T.]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T.]]
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[[Category: Lehtio L]]
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[[Category: Lehtio, L.]]
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[[Category: Moche M]]
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[[Category: Moche, M.]]
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[[Category: Nilsson ME]]
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[[Category: Nilsson, M E.]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P.]]
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[[Category: Nyman T]]
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[[Category: Nyman, T.]]
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[[Category: Olesen K]]
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[[Category: Olesen, K.]]
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[[Category: Persson C]]
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[[Category: Persson, C.]]
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[[Category: Sagemark J]]
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[[Category: Sagemark, J.]]
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[[Category: Schueler H]]
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[[Category: Schueler, H.]]
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[[Category: Thorsell AG]]
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[[Category: Thorsell, A G.]]
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[[Category: Tresaugues L]]
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[[Category: Tresaugues, L.]]
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[[Category: Van Den Berg S]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Welin, M.]]
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[[Category: Welin M]]
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[[Category: Wikstrom, M.]]
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[[Category: Wikstrom M]]
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[[Category: Wisniewska, M.]]
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[[Category: Wisniewska M]]
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[[Category: 5-oxo-l-norleucine]]
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[[Category: Ctp synthetase]]
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[[Category: Ctp]]
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[[Category: Cytidine 5'- triphosphate synthetase 2]]
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[[Category: Don]]
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[[Category: Glutaminase domain]]
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[[Category: Glutamine amidotransferase]]
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[[Category: Ligase]]
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[[Category: Nucleotide metabolism]]
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[[Category: Phosphoprotein]]
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[[Category: Pyrimidine biosynthesis]]
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[[Category: Utp-- ammonia ligase 2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 8 09:23:35 2008''
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Current revision

Human CTP synthetase 2 - glutaminase domain in complex with 5-OXO-L- NORLEUCINE

PDB ID 2v4u

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