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2v5o

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==STRUCTURE OF HUMAN IGF2R DOMAINS 11-14==
==STRUCTURE OF HUMAN IGF2R DOMAINS 11-14==
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<StructureSection load='2v5o' size='340' side='right' caption='[[2v5o]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
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<StructureSection load='2v5o' size='340' side='right'caption='[[2v5o]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2v5o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2v5o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V5O FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e6f|1e6f]], [[1gp0|1gp0]], [[1gp3|1gp3]], [[1gqb|1gqb]], [[1jpl|1jpl]], [[1jwg|1jwg]], [[1lf8|1lf8]], [[2cnj|2cnj]], [[2v5n|2v5n]], [[2v5p|2v5p]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v5o RCSB], [http://www.ebi.ac.uk/pdbsum/2v5o PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5o OCA], [https://pdbe.org/2v5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v5o RCSB], [https://www.ebi.ac.uk/pdbsum/2v5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5o ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5o_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5o_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v5o ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2v5o" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boxel, G Van.]]
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[[Category: Large Structures]]
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[[Category: Brown, J.]]
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[[Category: Brown J]]
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[[Category: Delaine, C.]]
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[[Category: Delaine C]]
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[[Category: Denley, A.]]
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[[Category: Denley A]]
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[[Category: Forbes, B E.]]
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[[Category: Forbes BE]]
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[[Category: Gilbert, R J.]]
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[[Category: Gilbert RJ]]
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[[Category: Hassan, A B.]]
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[[Category: Hassan AB]]
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[[Category: Jones, E Y.]]
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[[Category: Jones EY]]
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[[Category: Siebold, C.]]
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[[Category: Siebold C]]
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[[Category: Wallace, J C.]]
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[[Category: Wallace JC]]
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[[Category: Zaccheo, O J.]]
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[[Category: Zaccheo OJ]]
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[[Category: Beta barrel]]
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[[Category: Van Boxel G]]
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[[Category: Cation independent mannose 6-phosphate]]
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[[Category: Fibronectin type ii]]
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[[Category: Glycoprotein]]
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[[Category: Insulin-like growth factor]]
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[[Category: Lysosome]]
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[[Category: Membrane]]
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[[Category: Phosphorylation]]
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[[Category: Receptor]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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Current revision

STRUCTURE OF HUMAN IGF2R DOMAINS 11-14

PDB ID 2v5o

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