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2v90
From Proteopedia
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| - | [[Image:2v90.jpg|left|200px]]<br /><applet load="2v90" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2v90, resolution 2.00Å" /> | ||
| - | '''CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF INTESTINE- AND KIDNEY-ENRICHED PDZ DOMAIN IKEPP (PDZD3)'''<br /> | ||
| - | == | + | ==Crystal structure of the 3rd PDZ domain of intestine- and kidney- enriched PDZ domain IKEPP (PDZD3)== |
| - | + | <StructureSection load='2v90' size='340' side='right'caption='[[2v90]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[2v90]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V90 FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v90 OCA], [https://pdbe.org/2v90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v90 RCSB], [https://www.ebi.ac.uk/pdbsum/2v90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v90 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/NHRF4_HUMAN NHRF4_HUMAN] Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).<ref>PMID:11950846</ref> <ref>PMID:19088451</ref> | |
| - | [ | + | == Evolutionary Conservation == |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v90_consurf.spt"</scriptWhenChecked> | |
| - | [[ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v90 ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | [ | + | |
| - | [[ | + | |
| - | [ | + | |
| - | + | ||
| - | + | ||
| - | + | ==See Also== | |
| + | *[[Sodium-hydrogen exchange regulatory factor 3D structures|Sodium-hydrogen exchange regulatory factor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bunkoczi G]] | ||
| + | [[Category: Cooper C]] | ||
| + | [[Category: Doyle DA]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Elkins J]] | ||
| + | [[Category: Gileadi C]] | ||
| + | [[Category: Phillips C]] | ||
| + | [[Category: Pike ACW]] | ||
| + | [[Category: Salah E]] | ||
| + | [[Category: Sundstrom M]] | ||
| + | [[Category: Ugochukwu E]] | ||
| + | [[Category: Uppenberg J]] | ||
| + | [[Category: Weigelt J]] | ||
Current revision
Crystal structure of the 3rd PDZ domain of intestine- and kidney- enriched PDZ domain IKEPP (PDZD3)
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bunkoczi G | Cooper C | Doyle DA | Edwards A | Elkins J | Gileadi C | Phillips C | Pike ACW | Salah E | Sundstrom M | Ugochukwu E | Uppenberg J | Weigelt J
