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2vaq
From Proteopedia
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==STRUCTURE OF STRICTOSIDINE SYNTHASE IN COMPLEX WITH INHIBITOR== | ==STRUCTURE OF STRICTOSIDINE SYNTHASE IN COMPLEX WITH INHIBITOR== | ||
| - | <StructureSection load='2vaq' size='340' side='right' caption='[[2vaq]], [[Resolution|resolution]] 3.01Å' scene=''> | + | <StructureSection load='2vaq' size='340' side='right'caption='[[2vaq]], [[Resolution|resolution]] 3.01Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2vaq]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2vaq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VAQ FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VAW:(2S,3R,4S)-METHYL+4-(2-(2-(1H-INDOL-3-YL)ETHYLAMINO)ETHYL)-2-((2S,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YLOXY)-3-VINYL-3,4-DIHYDRO-2H-PYRAN-5-CARBOXYLATE'>VAW</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VAW:(2S,3R,4S)-METHYL+4-(2-(2-(1H-INDOL-3-YL)ETHYLAMINO)ETHYL)-2-((2S,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YLOXY)-3-VINYL-3,4-DIHYDRO-2H-PYRAN-5-CARBOXYLATE'>VAW</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vaq OCA], [https://pdbe.org/2vaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vaq RCSB], [https://www.ebi.ac.uk/pdbsum/2vaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vaq ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/va/2vaq_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/va/2vaq_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vaq ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2vaq" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Rauvolfia serpentina]] | [[Category: Rauvolfia serpentina]] | ||
| - | + | [[Category: Friedrich A]] | |
| - | [[Category: Friedrich | + | [[Category: Giddings LA]] |
| - | [[Category: Giddings | + | [[Category: Loris EA]] |
| - | [[Category: Loris | + | [[Category: Maresh J]] |
| - | [[Category: Maresh | + | [[Category: O'Connor SE]] |
| - | [[Category: | + | [[Category: Panjikar S]] |
| - | [[Category: Panjikar | + | [[Category: Peters B]] |
| - | [[Category: Peters | + | [[Category: Stoeckigt J]] |
| - | [[Category: Stoeckigt | + | [[Category: Trout BL]] |
| - | [[Category: Trout | + | |
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Current revision
STRUCTURE OF STRICTOSIDINE SYNTHASE IN COMPLEX WITH INHIBITOR
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