2vna
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2vna is ON HOLD Authors: Shafqat, N., Kavanagh, K., Pike, A.C.W., Pilka, E., Roos, A.K., Picaud, S., Johansson, C., Smee, C., Fedorov, O., Kochan, G...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Human Zinc-binding Alcohol Dehydrogenase 1 (ZADH1)== | |
| + | <StructureSection load='2vna' size='340' side='right'caption='[[2vna]], [[Resolution|resolution]] 2.17Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2vna]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VNA FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vna OCA], [https://pdbe.org/2vna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vna RCSB], [https://www.ebi.ac.uk/pdbsum/2vna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vna ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PTGR2_HUMAN PTGR2_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).<ref>PMID:19000823</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vna_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vna ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Fedorov O]] | ||
| + | [[Category: Johansson C]] | ||
| + | [[Category: Kavanagh K]] | ||
| + | [[Category: Kochan G]] | ||
| + | [[Category: Muniz JRC]] | ||
| + | [[Category: Opperman U]] | ||
| + | [[Category: Picaud S]] | ||
| + | [[Category: Pike ACW]] | ||
| + | [[Category: Pilka E]] | ||
| + | [[Category: Roos AK]] | ||
| + | [[Category: Shafqat N]] | ||
| + | [[Category: Smee C]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Structure of Human Zinc-binding Alcohol Dehydrogenase 1 (ZADH1)
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Edwards A | Fedorov O | Johansson C | Kavanagh K | Kochan G | Muniz JRC | Opperman U | Picaud S | Pike ACW | Pilka E | Roos AK | Shafqat N | Smee C | Weigelt J | Von Delft F
