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2vp8

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==STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS RV1207==
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<StructureSection load='2vp8' size='340' side='right' caption='[[2vp8]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
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==Structure of Mycobacterium tuberculosis Rv1207==
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<StructureSection load='2vp8' size='340' side='right'caption='[[2vp8]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vp8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VP8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vp8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VP8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.5.15 2.1.5.15] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vp8 OCA], [http://pdbe.org/2vp8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vp8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vp8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vp8 OCA], [https://pdbe.org/2vp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vp8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vp8 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHPS2_MYCTU DHPS2_MYCTU] Has very low affinity for the DHPS substrate 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism.<ref>PMID:18680522</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vp8_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vp8_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Dihydropteroate synthase|Dihydropteroate synthase]]
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*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Myctu]]
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[[Category: Large Structures]]
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[[Category: Transferase]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Dick, T]]
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[[Category: Dick T]]
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[[Category: Gengenbacher, M]]
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[[Category: Gengenbacher M]]
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[[Category: Niyomwattanakit, P]]
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[[Category: Niyomwattanakit P]]
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[[Category: Spraggon, G]]
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[[Category: Spraggon G]]
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[[Category: Xu, T]]
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[[Category: Xu T]]
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[[Category: Antibiotic resistance]]
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[[Category: Dihydropteroate synthase]]
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[[Category: Folate biosynthesis]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Rv1207]]
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Current revision

Structure of Mycobacterium tuberculosis Rv1207

PDB ID 2vp8

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