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2vqu

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==Structural and biochemical evidence for a boat-like transition state in beta-mannosidases==
==Structural and biochemical evidence for a boat-like transition state in beta-mannosidases==
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<StructureSection load='2vqu' size='340' side='right' caption='[[2vqu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='2vqu' size='340' side='right'caption='[[2vqu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VQU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VQU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NOY:(2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL'>NOY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vot|2vot]], [[2vqt|2vqt]], [[2vl4|2vl4]], [[2vo5|2vo5]], [[2je8|2je8]], [[2vjx|2vjx]], [[2vmf|2vmf]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NOY:(2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL'>NOY</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-mannosidase Beta-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.25 3.2.1.25] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqu OCA], [https://pdbe.org/2vqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vqu RCSB], [https://www.ebi.ac.uk/pdbsum/2vqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vqu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqu OCA], [http://pdbe.org/2vqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vqu RCSB], [http://www.ebi.ac.uk/pdbsum/2vqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vqu ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8AAK6_BACTN Q8AAK6_BACTN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Mannosidase|Mannosidase]]
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*[[Mannosidase 3D structures|Mannosidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus thetaiotaomicron distaso 1912]]
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[[Category: Bacteroides thetaiotaomicron]]
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[[Category: Beta-mannosidase]]
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[[Category: Large Structures]]
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[[Category: Bleriot, Y]]
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[[Category: Bleriot Y]]
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[[Category: Davies, G J]]
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[[Category: Davies GJ]]
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[[Category: Dumon, C]]
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[[Category: Dumon C]]
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[[Category: Gilbert, H J]]
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[[Category: Gilbert HJ]]
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[[Category: Gratien, J]]
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[[Category: Gratien J]]
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[[Category: Heck, M P]]
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[[Category: Heck MP]]
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[[Category: Moreland, C]]
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[[Category: Moreland C]]
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[[Category: Offen, W A]]
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[[Category: Offen WA]]
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[[Category: Smith, N L]]
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[[Category: Smith NL]]
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[[Category: Stick, R V]]
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[[Category: Stick RV]]
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[[Category: Tailford, L E]]
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[[Category: Tailford LE]]
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[[Category: Vasella, A]]
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[[Category: Vasella A]]
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[[Category: Glycoside hydrolase]]
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[[Category: Hydrolase]]
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[[Category: Linear free energy relationship]]
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[[Category: Mannosidase]]
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[[Category: Transition state mimic]]
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Current revision

Structural and biochemical evidence for a boat-like transition state in beta-mannosidases

PDB ID 2vqu

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