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2vrp

From Proteopedia

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{{Seed}}
 
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[[Image:2vrp.png|left|200px]]
 
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==Structure of rhodocytin==
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The line below this paragraph, containing "STRUCTURE_2vrp", creates the "Structure Box" on the page.
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<StructureSection load='2vrp' size='340' side='right'caption='[[2vrp]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vrp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VRP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_2vrp| PDB=2vrp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vrp OCA], [https://pdbe.org/2vrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vrp RCSB], [https://www.ebi.ac.uk/pdbsum/2vrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vrp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SLYA_CALRH SLYA_CALRH]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vrp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vrp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Binding of the snake venom protein rhodocytin to CLEC-2, a receptor on the surface of human platelets, initiates a signaling cascade leading to platelet activation and aggregation. We have previously solved the structure of CLEC-2. The 2.4 A resolution crystal structure of rhodocytin presented here demonstrates that it is the first snake venom or other C-type lectin-like protein to assemble as a non-disulfide linked (alphabeta)(2) tetramer. Rhodocytin is highly adapted for interaction with CLEC-2 and displays a concave binding surface, which is highly complementary to the experimentally determined binding interface on CLEC-2. Using computational dynamic methods, surface electrostatic charge and hydrophobicity analyses, and protein-protein docking predictions, we propose that the (alphabeta)(2) rhodocytin tetramer induces clustering of CLEC-2 receptors on the platelet surface, which will trigger major signaling events resulting in platelet activation and aggregation.
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===STRUCTURE OF RHODOCYTIN===
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Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2.,Watson AA, Eble JA, O'Callaghan CA Protein Sci. 2008 Sep;17(9):1611-6. Epub 2008 Jun 26. PMID:18583525<ref>PMID:18583525</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18583525}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2vrp" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18583525 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18583525}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2VRP is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRP OCA].
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==Reference==
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Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2., Watson AA, Eble JA, O'Callaghan CA, Protein Sci. 2008 Jun 26;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18583525 18583525]
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[[Category: Calloselasma rhodostoma]]
[[Category: Calloselasma rhodostoma]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Callaghan, C A.O.]]
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[[Category: O'Callaghan CA]]
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[[Category: Watson, A A.]]
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[[Category: Watson AA]]
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[[Category: Aggretin]]
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[[Category: C-type lectin-like]]
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[[Category: Clec-2]]
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[[Category: Lectin]]
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[[Category: Sugar-binding protein]]
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[[Category: Venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 16 08:54:56 2008''
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Current revision

Structure of rhodocytin

PDB ID 2vrp

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