This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2vsv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2vsv" [edit=sysop:move=sysop])
Current revision (15:31, 13 December 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2vsv.png|left|200px]]
 
-
{{STRUCTURE_2vsv| PDB=2vsv | SCENE= }}
+
==Crystal structure of the PDZ domain of human rhophilin-2==
-
 
+
<StructureSection load='2vsv' size='340' side='right'caption='[[2vsv]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
-
===CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN RHOPHILIN-2===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2vsv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VSV FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsv OCA], [https://pdbe.org/2vsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vsv RCSB], [https://www.ebi.ac.uk/pdbsum/2vsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsv ProSAT]</span></td></tr>
-
[[2vsv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSV OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RHPN2_HUMAN RHPN2_HUMAN] Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.<ref>PMID:12221077</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/2vsv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vsv ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Bountra, C.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Burgess-Brown, N.]]
+
[[Category: Bountra C]]
-
[[Category: Delft, F Von.]]
+
[[Category: Burgess-Brown N]]
-
[[Category: Edwards, A.]]
+
[[Category: Edwards A]]
-
[[Category: Elkins, J.]]
+
[[Category: Elkins J]]
-
[[Category: Kochan, G.]]
+
[[Category: Kochan G]]
-
[[Category: Murray, J W.]]
+
[[Category: Murray JW]]
-
[[Category: Oppermann, U.]]
+
[[Category: Oppermann U]]
-
[[Category: Pike, A C.W.]]
+
[[Category: Pike ACW]]
-
[[Category: Pilka, E S.]]
+
[[Category: Pilka ES]]
-
[[Category: Roos, A.]]
+
[[Category: Roos A]]
-
[[Category: Shafqat, N.]]
+
[[Category: Shafqat N]]
-
[[Category: Sun, Z.]]
+
[[Category: Sun Z]]
-
[[Category: Wikstrom, M.]]
+
[[Category: Wikstrom M]]
-
[[Category: Casp8]]
+
[[Category: Von Delft F]]
-
[[Category: Nitration]]
+
-
[[Category: Pdz domain]]
+
-
[[Category: Protein-binding]]
+
-
[[Category: Rho gtpase binding]]
+
-
[[Category: Rhob]]
+
-
[[Category: Scaffold protein]]
+

Current revision

Crystal structure of the PDZ domain of human rhophilin-2

PDB ID 2vsv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vsv"
Personal tools