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2vxm

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==SCREENING A LIMITED STRUCTURE-BASED LIBRARY IDENTIFIES UDP-GALNAC-SPECIFIC MUTANTS OF ALPHA-1,3 GALACTOSYLTRANSFERASE==
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<StructureSection load='2vxm' size='340' side='right' caption='[[2vxm]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
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==Screening a Limited Structure-based Library Identifies UDP-GalNAc- Specific Mutants of alpha-1,3 Galactosyltransferase==
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<StructureSection load='2vxm' size='340' side='right'caption='[[2vxm]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vxm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vxm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VXM FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.82&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vxl|2vxl]], [[2vs4|2vs4]], [[1vzt|1vzt]], [[1gx0|1gx0]], [[1vzx|1vzx]], [[1o7q|1o7q]], [[2vs5|2vs5]], [[1gx4|1gx4]], [[2jcj|2jcj]], [[2jck|2jck]], [[2vfz|2vfz]], [[1g93|1g93]], [[1k4v|1k4v]], [[1gwv|1gwv]], [[1g8o|1g8o]], [[2vs3|2vs3]], [[1vzu|1vzu]], [[1o7o|1o7o]], [[2jcl|2jcl]], [[1gww|1gww]], [[1fg5|1fg5]], [[2jco|2jco]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetyllactosaminide_3-alpha-galactosyltransferase N-acetyllactosaminide 3-alpha-galactosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.87 2.4.1.87] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxm OCA], [https://pdbe.org/2vxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vxm RCSB], [https://www.ebi.ac.uk/pdbsum/2vxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxm ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vxm RCSB], [http://www.ebi.ac.uk/pdbsum/2vxm PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/GGTA1_BOVIN GGTA1_BOVIN] Transfer of galactose from UDP-galactose to an acceptor molecule (R).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/2vxm_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/2vxm_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vxm ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2vxm" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Glycosyltransferase|Glycosyltransferase]]
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: N-acetyllactosaminide 3-alpha-galactosyltransferase]]
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[[Category: Large Structures]]
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[[Category: Acharya, K R.]]
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[[Category: Acharya KR]]
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[[Category: Brew, K.]]
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[[Category: Brew K]]
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[[Category: Jamaluddin, H.]]
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[[Category: Jamaluddin H]]
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[[Category: Thiyagarajan, N.]]
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[[Category: Thiyagarajan N]]
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[[Category: Tumbale, P.]]
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[[Category: Tumbale P]]
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[[Category: 3 galactosyltransferase]]
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[[Category: Alpha-1]]
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[[Category: Enzyme mechanism]]
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[[Category: Glycoprotein]]
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[[Category: Glycosyltransferase]]
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[[Category: Glycosyltransferase galactosyltransferase]]
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[[Category: Golgi apparatus]]
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[[Category: Manganese]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Signal-anchor]]
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[[Category: Transferase]]
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[[Category: Transferase substrate specificity]]
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[[Category: Transmembrane]]
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Current revision

Screening a Limited Structure-based Library Identifies UDP-GalNAc- Specific Mutants of alpha-1,3 Galactosyltransferase

PDB ID 2vxm

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