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2vz6

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Current revision (15:38, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2vz6' size='340' side='right'caption='[[2vz6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2vz6' size='340' side='right'caption='[[2vz6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZ6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZ6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEF:(2Z,3E)-2,3-BIINDOLE-2,3(1H,1H)-DIONE+3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}'>FEF</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEF:(2Z,3E)-2,3-BIINDOLE-2,3(1H,1H)-DIONE+3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}'>FEF</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vz6 OCA], [https://pdbe.org/2vz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vz6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vz6 OCA], [https://pdbe.org/2vz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vz6 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCC2A_HUMAN KCC2A_HUMAN] CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Calcium/calmodulin-dependent protein kinase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Burgess-Brown, N]]
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[[Category: Burgess-Brown N]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Fedorov O]]
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[[Category: Fedorov, O]]
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[[Category: King O]]
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[[Category: King, O]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Murray JW]]
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[[Category: Murray, J W]]
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[[Category: Parizotto E]]
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[[Category: Parizotto, E]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W]]
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[[Category: Rellos P]]
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[[Category: Rellos, P]]
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[[Category: Roos A]]
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[[Category: Roos, A]]
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[[Category: Salah E]]
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[[Category: Salah, E]]
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[[Category: Shrestha L]]
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[[Category: Shrestha, L]]
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[[Category: Wikstroem M]]
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[[Category: Wikstroem, M]]
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[[Category: Von Delft F]]
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[[Category: Atp-binding]]
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[[Category: Brain]]
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[[Category: Calmodulin-binding]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Kinase]]
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[[Category: Long term potentiation]]
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[[Category: Membrane]]
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[[Category: Nmda receptor signalling]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Synapse]]
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[[Category: Transferase]]
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Current revision

Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804

PDB ID 2vz6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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