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2w0f

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==Potassium Channel KcsA-Fab Complex with Tetraoctylammonium==
==Potassium Channel KcsA-Fab Complex with Tetraoctylammonium==
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<StructureSection load='2w0f' size='340' side='right' caption='[[2w0f]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='2w0f' size='340' side='right'caption='[[2w0f]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2w0f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2w0f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W0F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=HX0:N,N,N-TRIOCTYLOCTAN-1-AMINIUM'>HX0</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r3k|1r3k]], [[2a9h|2a9h]], [[1k4d|1k4d]], [[1k4c|1k4c]], [[2hg5|2hg5]], [[2bob|2bob]], [[1f6g|1f6g]], [[2boc|2boc]], [[1jq2|1jq2]], [[1r3j|1r3j]], [[1jvm|1jvm]], [[1jq1|1jq1]], [[2ih3|2ih3]], [[1zwi|1zwi]], [[1bl8|1bl8]], [[1r3i|1r3i]], [[2ih1|2ih1]], [[1j95|1j95]], [[2h8p|2h8p]], [[1r3l|1r3l]], [[2atk|2atk]], [[4uuj|4uuj]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=HX0:N,N,N-TRIOCTYLOCTAN-1-AMINIUM'>HX0</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0f OCA], [http://pdbe.org/2w0f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w0f RCSB], [http://www.ebi.ac.uk/pdbsum/2w0f PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0f OCA], [https://pdbe.org/2w0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w0f RCSB], [https://www.ebi.ac.uk/pdbsum/2w0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
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[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/2w0f_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/2w0f_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Antibody|Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Monoclonal Antibody|Monoclonal Antibody]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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*[[Potassium Channel|Potassium Channel]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Actinomyces lividans krasil'nikov et al. 1965]]
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[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Focia, P J]]
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[[Category: Streptomyces lividans]]
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[[Category: Gross, A]]
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[[Category: Focia PJ]]
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[[Category: Lenaeus, M J]]
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[[Category: Gross A]]
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[[Category: Wagner, T]]
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[[Category: Lenaeus MJ]]
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[[Category: Immune system metal transport complex]]
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[[Category: Wagner T]]
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[[Category: Immune system-metal transport complex]]
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[[Category: Ion transport]]
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[[Category: Ionic channel]]
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[[Category: Potassium channel]]
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[[Category: Protein-antibody fab complex]]
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[[Category: Quaternary ammonium]]
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Current revision

Potassium Channel KcsA-Fab Complex with Tetraoctylammonium

PDB ID 2w0f

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