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2w0i

From Proteopedia

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{{Seed}}
 
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[[Image:2w0i.png|left|200px]]
 
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<!--
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==Structure Of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain Of Human Twinfilin-2==
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The line below this paragraph, containing "STRUCTURE_2w0i", creates the "Structure Box" on the page.
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<StructureSection load='2w0i' size='340' side='right'caption='[[2w0i]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2w0i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W0I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0i OCA], [https://pdbe.org/2w0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w0i RCSB], [https://www.ebi.ac.uk/pdbsum/2w0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0i ProSAT]</span></td></tr>
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{{STRUCTURE_2w0i| PDB=2w0i | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TWF2_HUMAN TWF2_HUMAN] Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/2w0i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w0i ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF C-TERMINAL ACTIN DEPOLYMERIZING FACTOR HOMOLOGY (ADF-H) DOMAIN OF HUMAN TWINFILIN-2===
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==See Also==
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*[[Twinfilin|Twinfilin]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2W0I is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0I OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Delft, F Von.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Elkins, J M.]]
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[[Category: Elkins JM]]
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[[Category: Knapp, S.]]
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[[Category: Knapp S]]
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[[Category: Murray, J W.]]
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[[Category: Murray JW]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike ACW]]
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[[Category: Roos, A.]]
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[[Category: Roos A]]
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[[Category: Salah, E.]]
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[[Category: Salah E]]
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[[Category: Savitsky, P.]]
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[[Category: Savitsky P]]
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[[Category: Wikstrom, M.]]
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[[Category: Wikstrom M]]
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[[Category: Acetylation]]
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[[Category: Von Delft F]]
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[[Category: Actin binding]]
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[[Category: Actin depolymerizing factor]]
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[[Category: Actin-binding]]
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[[Category: Cofilin-like]]
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[[Category: Cytoplasm]]
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[[Category: Cytoskeleton]]
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[[Category: Phosphoprotein]]
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[[Category: Phosphorylation]]
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[[Category: Polymorphism]]
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[[Category: Protein tyrosine kinase-9]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:20:51 2009''
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Current revision

Structure Of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain Of Human Twinfilin-2

PDB ID 2w0i

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