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2w10

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==MONA SH3C IN COMPLEX==
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<StructureSection load='2w10' size='340' side='right' caption='[[2w10]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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==Mona SH3C in complex==
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<StructureSection load='2w10' size='340' side='right'caption='[[2w10]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2w10]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W10 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2w10]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W10 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2d0n|2d0n]], [[1r1q|1r1q]], [[1h3h|1h3h]], [[1r1s|1r1s]], [[1oeb|1oeb]], [[1uti|1uti]], [[1r1p|1r1p]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w10 OCA], [https://pdbe.org/2w10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w10 RCSB], [https://www.ebi.ac.uk/pdbsum/2w10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w10 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w10 OCA], [http://pdbe.org/2w10 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w10 RCSB], [http://www.ebi.ac.uk/pdbsum/2w10 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTN23_MOUSE PTN23_MOUSE]] May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
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[https://www.uniprot.org/uniprot/GRAP2_MOUSE GRAP2_MOUSE] Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w1/2w10_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w1/2w10_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Mus musculus]]
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[[Category: Feller, S M]]
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[[Category: Feller SM]]
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[[Category: Harkiolaki, M]]
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[[Category: Harkiolaki M]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Dimer]]
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[[Category: Gad]]
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[[Category: Hd-ptp]]
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[[Category: Hydrolase]]
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[[Category: Mona]]
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[[Category: Phosphoprotein]]
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[[Category: Protein phosphatase]]
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[[Category: Sh2 domain]]
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[[Category: Sh3]]
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[[Category: Sh3 domain]]
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[[Category: Sh3 domain-complex]]
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[[Category: Signal tranduction]]
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[[Category: Tpr repeat]]
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Current revision

Mona SH3C in complex

PDB ID 2w10

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