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2w2j
From Proteopedia
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==Crystal structure of the human carbonic anhydrase related protein VIII== | ==Crystal structure of the human carbonic anhydrase related protein VIII== | ||
| - | <StructureSection load='2w2j' size='340' side='right' caption='[[2w2j]], [[Resolution|resolution]] 1.60Å' scene=''> | + | <StructureSection load='2w2j' size='340' side='right'caption='[[2w2j]], [[Resolution|resolution]] 1.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2w2j]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2w2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W2J FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2j OCA], [https://pdbe.org/2w2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w2j RCSB], [https://www.ebi.ac.uk/pdbsum/2w2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2j ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN] Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3) [MIM:[https://omim.org/entry/613227 613227]. CMARQ3 is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN] Does not have a carbonic anhydrase catalytic activity. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w2j_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w2j_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w2j ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Carbonate dehydratase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith C]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Filippakopoulos | + | [[Category: Filippakopoulos P]] |
| - | [[Category: King | + | [[Category: King ONF]] |
| - | [[Category: Kochan | + | [[Category: Kochan G]] |
| - | [[Category: Kramm | + | [[Category: Kramm A]] |
| - | [[Category: Muniz | + | [[Category: Muniz JRC]] |
| - | [[Category: Oppermann | + | [[Category: Oppermann U]] |
| - | [[Category: Picaud | + | [[Category: Picaud SS]] |
| - | [[Category: Pike | + | [[Category: Pike ACW]] |
| - | [[Category: Pilka | + | [[Category: Pilka ES]] |
| - | [[Category: Wikstrom | + | [[Category: Wikstrom M]] |
| - | [[Category: Yue | + | [[Category: Yue WW]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
| - | + | ||
Current revision
Crystal structure of the human carbonic anhydrase related protein VIII
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Bountra C | Edwards A | Filippakopoulos P | King ONF | Kochan G | Kramm A | Muniz JRC | Oppermann U | Picaud SS | Pike ACW | Pilka ES | Wikstrom M | Yue WW | Von Delft F
